典型文献
Lepr+mesenchymal cells sense diet to modulate intestinal stem/progenitor cells via Leptin-Igf1 axis
文献摘要：
Diet can impact on gut health and disease by modulating intestinal stem cells(ISCs).However,it is largely unknown if and how the ISC niche responds to diet and influences ISC function.Here,we demonstrate that Lepr+mesenchymal cells(MCs)surrounding intestinal crypts sense diet change and provide a novel niche signal to maintain ISC and progenitor cell proliferation.The abundance of these MCs increases upon administration of a high-fat diet(HFD)but dramatically decreases upon fasting.Depletion of Lepr+MCs resulted in fewer intestinal stem/progenitor cells,compromised the architecture of crypt-villus axis and impaired intestinal regeneration.Furthermore,we showed that IGF1 secreted by Lepr+MCs is an important effector that promotes proliferation of ISCs and progenitor cells in the intestinal crypt.We conclude that Lepr+MCs sense diet alterations and,in turn,modulate intestinal stem/progenitor cell function via a stromal IGF1-epithelial IGF1R axis.These findings reveal that Lepr+MCs are important mediators linking systemic diet changes to local ISC function and might serve as a novel therapeutic target for gut diseases.
文献关键词：
中图分类号：
作者姓名：
Min Deng;Christian F.Guerrero-Juarez;Xiaole Sheng;Jiuzhi Xu;Xi Wu;Kai Yao;Mengzhen Li;Xu Yang;Guilin Li;Jintao Xiao;Xiaowei Liu;Kaichun Wu;Fazheng Ren;Qing Nie;Maksim V.Plikus;Zhengquan Yu;Cong Lv
作者机构：
Key Laboratory of Precision Nutrition and Food Quality,Ministry of Education,Department of Nutrition and Health,College of Biological Sciences,China Agricultural University,Beijing,China;Department of Mathematics,NSF-Simons Center for Multiscale Cell Fate Research,Center for Complex Biological Systems,University of California,Irvine,CA,USA;Department of Developmental and Cell Biology,Sue and Bill Gross Stem Cell Research Center,University of California,Irvine,CA,USA;Department of Gastroenterology,Xiangya Hospital of Central South University,Changsha,Hunan,China;Department of Gastroenterology,Xijing Hospital,The Fourth Military Medical University,Xi'an,Shaanxi,China;State Key Laboratories for Agrobiotechnology,College of Biological Sciences,China Agricultural University,Beijing,China
文献出处：
引用格式：
[1]Min Deng;Christian F.Guerrero-Juarez;Xiaole Sheng;Jiuzhi Xu;Xi Wu;Kai Yao;Mengzhen Li;Xu Yang;Guilin Li;Jintao Xiao;Xiaowei Liu;Kaichun Wu;Fazheng Ren;Qing Nie;Maksim V.Plikus;Zhengquan Yu;Cong Lv-.Lepr+mesenchymal cells sense diet to modulate intestinal stem/progenitor cells via Leptin-Igf1 axis)[J].细胞研究（英文版）,2022(07):670-686
A类：
Lepr+mesenchymal,Lepr+MCs
B类：
cells,sense,diet,modulate,intestinal,progenitor,via,Leptin,Igf1,axis,Diet,can,impact,gut,health,by,modulating,ISCs,However,largely,unknown,niche,responds,influences,function,Here,demonstrate,that,surrounding,crypts,provide,novel,signal,maintain,proliferation,abundance,these,increases,upon,administration,high,fat,HFD,but,dramatically,decreases,fasting,Depletion,resulted,fewer,compromised,architecture,villus,impaired,regeneration,Furthermore,showed,secreted,important,effector,promotes,We,conclude,alterations,turn,stromal,epithelial,IGF1R,These,findings,reveal,are,mediators,linking,systemic,changes,local,might,serve,therapeutic,target,diseases
AB值：
0.487262
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
