Dysregulated energy metabolism has recently been recognized as an emerging hallmark of cancer.Tumor cells,which are characterized by abnormal glycolysis,exhibit a lower extracellular pH (6.5-7.0) than nor-mal tissues (7.2-7.4),providing a promising target for tumor-specific imaging and therapy.However,most pH-sensitive materials are unable to distinguish such a subtle pH difference owing to their wide and continuous pH-responsive range.In this study,we developed an efficient strategy for the fabrication of a tumor metabolic acidity-activatable calcium phosphate (CaP) fluorescent probe (termed MACaP9).Unlike traditional CaP-based biomedical nanomaterials,which only work within more acidic organelles,such as endosomes and lysosomes (pH 4.0-6.0),MACaP9 could not only specifically respond to the tumor extra-cellular pH but also rapidly convert pH variations into a distinct fluorescence signal to visually dis-tinguish tumor from normal tissues.The superior sensitivity and specificity of MACaP9 enabled high-contrast visualization of a broad range of tumors,as well as small tumor lesions.

Qian Jia;Ruili Zhang;Yongdong Wang;Haohao Yan;Zheng Li;Yanbin Feng;Yu Ji;ZUO Yang;Yang Yang;Kanyi Pu;Zhongliang Wang

Laboratory of Molecular Imaging and Translational Medicine (MITM),Engineering Research Center of Molecular & Neuroimaging,Ministry of Education,School of Life Science and Technology,Xidian University,Xi'an 710126,China;Department of Thoracic Surgery,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai 200433,China;School of Materials Science and Engineering,Tongji University,Shanghai 201804,China;School of Chemical and Biomedical Engineering,Nanyang Technological University,Singapore 637457,Singapore;Academy of Advanced Interdisciplinary Research,Xidian University,Xi'an 710071,China

科学通报（英文版）

[1]Qian Jia;Ruili Zhang;Yongdong Wang;Haohao Yan;Zheng Li;Yanbin Feng;Yu Ji;ZUO Yang;Yang Yang;Kanyi Pu;Zhongliang Wang-.A metabolic acidity-activatable calcium phosphate probe with fluorescence signal amplification capabilities for non-invasive imaging of tumor malignancy)[J].科学通报（英文版）,2022(03):288-298

MACaP9,tinguish

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