典型文献
Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo
文献摘要：
Antrodia cinnamomea is extensively used as a traditional medicine to prevention and treat-ment of liver cancer.However,its comprehensive chemical fingerprint is uncertain,and the mechanisms,especially the potential therapeutic target for anti-hepatocellular carcinoma(HCC)are still unclear.Using UPLC-Q-TOF/MS,139 chemical components were identified in A.cinnamomea dropping pills(ACDPs).Based on these chemical components,network pharmacology demonstrated that the targets of active components were significantly enriched in the pathways in cancer,which were closely related with cell proliferation regulation.Next,HCC data was downloaded from Gene Expression Omnibus database(GEO).The Cancer Genome Atlas(TCGA)and DisGeNET were analyzed by bioinformatics,and 79 bio-markers were obtained.Furtherly,nine targets of ACDP active components were revealed,and they were significantly enriched in PI3K/AKT and cell cycle signaling pathways.The affinity between these targets and their corresponding active ingredients was predicted by molecular docking.Finally,in vivo and in vitro experiments showed that ACDPs could reduce the activity of PI3K/AKT signaling pathway and downregulate the expression of cell cycle-related proteins,contributing to the decreased growth of liver cancer.Altogether,PI3K/AKT-cell cycle appears as the significant central node in anti-liver cancer of A.Cinnamomea.
文献关键词：
中图分类号：
作者姓名：
Yan Zhang;Pin Lv;Junmei Ma;Ning Chen;Huishan Guo;Yan Chen;Xiaoruo Gan;Rong Wang;Xuqiang Liu;Sufang Fan;Bin Cong;Wenyi Kang
作者机构：
Hebei Key Laboratory of Forensic Medicine,College of Forensic Medicine,Hebei Medical University,Shijiazhuang 050017,China;Hebei Food Safety Key Laboratory,Hebei Food Inspection and Research Institute,Shijiazhuang 050091,China;Cardiovascular Medical Science Center Department of Cell Biology,Hebei Medical University,Shijiazhuang 050017,China;National R&D Center for Edible Fungus Processing Technology,Henan University,Kaifeng 475004,China;Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology,Chinese Academy of Medical Sciences,Beijing 100730,China
文献出处：
引用格式：
[1]Yan Zhang;Pin Lv;Junmei Ma;Ning Chen;Huishan Guo;Yan Chen;Xiaoruo Gan;Rong Wang;Xuqiang Liu;Sufang Fan;Bin Cong;Wenyi Kang-.Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo)[J].药学学报（英文版）,2022(02):890-906
A类：
ACDPs,ACDP,Cinnamomea
B类：
Antrodia,cinnamomea,exerts,anti,hepatoma,effect,by,targeting,PI3K,AKT,mediated,cycle,progression,vitro,vivo,extensively,used,traditional,medicine,prevention,treat,liver,cancer,However,its,comprehensive,chemical,fingerprint,uncertain,mechanisms,especially,potential,therapeutic,hepatocellular,carcinoma,HCC,are,still,unclear,Using,UPLC,TOF,components,were,identified,dropping,pills,Based,these,network,pharmacology,demonstrated,that,targets,active,significantly,enriched,pathways,which,closely,related,proliferation,regulation,Next,was,downloaded,from,Gene,Expression,Omnibus,database,GEO,Cancer,Genome,Atlas,TCGA,DisGeNET,analyzed,bioinformatics,markers,obtained,Furtherly,nine,revealed,they,signaling,affinity,between,their,corresponding,ingredients,predicted,molecular,docking,Finally,experiments,showed,could,reduce,activity,downregulate,expression,proteins,contributing,decreased,growth,Altogether,appears,central,node
AB值：
0.575517
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
