典型文献
Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses
文献摘要：
Pharmaceutical analysis is a discipline based on chemical,physical,biological,and informa-tion technologies.At present,biotechnological analysis is a short branch in pharmaceutical analysis;how-ever,bioanalysis is the basis and an important part of medicine.Biotechnological approaches can provide information on biological activity and even clinical efficacy and safety,which are important characteris-tics of drug quality.Because of their advantages in reflecting the overall biological effects or functions of drugs and providing visual and intuitive results,some biotechnological analysis methods have been grad-ually applied to pharmaceutical analysis from raw material to manufacturing and final product analysis,including DNA super-barcoding,DNA-based rapid detection,multiplex ligation-dependent probe ampli-fication,hyperspectral imaging combined with artificial intelligence,3D biologically printed organoids,omics-based artificial intelligence,microfluidic chips,organ-on-a-chip,signal transduction pathway-related reporter gene assays,and the zebrafish thrombosis model.The applications of these emerging bio-techniques in pharmaceutical analysis have been discussed in this review.
文献关键词：
中图分类号：
作者姓名：
Shilin Chen;Zheng Li;Sanyin Zhang;Yuxin Zhou;Xiaohe Xiao;Pengdi Cui;Binjie Xu;Qinghe Zhao;Shasha Kong;Yuntao Dai
作者机构：
Institute of Herbgenomics,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;State Key Laboratory of Component Traditional Chinese Medicine,College of Pharmaceutical Engineering of Traditional Chinese Medicine,Haihe Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;China Military Institute of Chinese Medicine,Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China
文献出处：
引用格式：
[1]Shilin Chen;Zheng Li;Sanyin Zhang;Yuxin Zhou;Xiaohe Xiao;Pengdi Cui;Binjie Xu;Qinghe Zhao;Shasha Kong;Yuntao Dai-.Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses)[J].药学学报（英文版）,2022(11):4075-4097
A类：
B类：
Emerging,biotechnology,applications,natural,product,synthetic,pharmaceutical,analyses,Pharmaceutical,discipline,chemical,physical,technologies,At,present,biotechnological,short,branch,how,ever,bioanalysis,basis,important,part,medicine,Biotechnological,approaches,can,provide,information,activity,even,clinical,efficacy,safety,which,are,characteris,tics,quality,Because,their,advantages,reflecting,overall,effects,functions,drugs,providing,visual,intuitive,results,some,methods,have,been,grad,ually,applied,from,raw,material,manufacturing,final,including,super,barcoding,rapid,detection,multiplex,ligation,dependent,probe,ampli,fication,hyperspectral,imaging,combined,artificial,intelligence,biologically,printed,organoids,omics,microfluidic,chips,signal,transduction,pathway,related,reporter,gene,assays,zebrafish,thrombosis,model,these,emerging,techniques,discussed,this,review
AB值：
0.708152
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