典型文献
Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein
文献摘要：
Ebola virus(EBOV)infection leads to staggeringly high mortality rate.Effective and low-cost treatments are urgently needed to control frequent EBOV outbreaks in Africa.In this study,we report that a natural compound called berbamine hydrochloride strongly inhibits EBOV replication in vitro and in vivo.Our work further showed that berbamine hydrochloride acts by directly binding to the cleaved EBOV glyco-protein(GPcl),disrupting GPcl interaction with viral receptor Niemann-Pick Cl,thus blocking the fusion of viral and cellular membranes.Our data support the probability of developing anti-EBOV small molecule drugs by targeting viral GPcl.More importantly,since berbamine hydrochloride has been used in clinic to treat leukopenia,it holds great promise of being quickly repurposed as an anti-EBOV drug.
文献关键词：
中图分类号：
作者姓名：
Dongrong Yi;Quanjie Li;Han Wang;Kai Lv;Ling Ma;Yujia Wang;Jing Wang;Yongxin Zhang;Mingliang Liu;Xiaoyu Li;Jianxun Qi;Yi Shi;George F.Gao;Shan Cen
作者机构：
Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical School,Beijing 100050,China;CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China;CAMS Key Laboratory of Antiviral Drug Research,Institute of Medicinal Biotechnology,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100050,China
文献出处：
引用格式：
[1]Dongrong Yi;Quanjie Li;Han Wang;Kai Lv;Ling Ma;Yujia Wang;Jing Wang;Yongxin Zhang;Mingliang Liu;Xiaoyu Li;Jianxun Qi;Yi Shi;George F.Gao;Shan Cen-.Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein)[J].药学学报（英文版）,2022(12):4378-4389
A类：
staggeringly,GPcl
B类：
Repurposing,berbamine,hydrochloride,Ebola,virus,by,targeting,viral,glycoprotein,EBOV,infection,leads,high,mortality,rate,Effective,low,cost,treatments,are,urgently,needed,control,frequent,outbreaks,Africa,In,this,study,report,that,natural,compound,called,strongly,inhibits,replication,vitro,vivo,Our,work,further,showed,acts,directly,binding,cleaved,disrupting,interaction,receptor,Niemann,Pick,Cl,thus,blocking,fusion,cellular,membranes,data,support,probability,developing,anti,small,molecule,drugs,More,importantly,since,has,been,used,clinic,leukopenia,holds,great,promise,being,quickly,repurposed
AB值：
0.599087
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
