典型文献
Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2
文献摘要：
In contrast to the extensive research about viral protein-host protein interactions that has revealed major insights about how RNA viruses engage with host cells during infection,few studies have examined interactions between host factors and viral RNAs(vRNAs).Here,we profiled vRNA-host protein interactomes for three RNA virus pathogens (SARS-CoV-2,Zika,and Ebola viruses)using ChIRP-MS.Comparative interactome analyses discovered both common and virus-specific host responses and vRNA-associated proteins that variously promote or restrict viral infection.In particular,SARS-CoV-2 binds and hijacks the host factor IGF2BP1 to stabilize vRNA and augment viral translation.Our interactome-informed drug repurposing efforts identified several FDA-approved drugs (e.g.,Cepharanthine) as broad-spectrum antivirals in cells and hACE2 transgenic mice.A co-treatment comprising Cepharanthine and Trifluoperazine was highly potent against the newly emerged SARS-CoV-2 B.1.351 variant.Thus,our study illustrates the scientific and medical discovery utility of adopting a comparative vRNA-host protein interactome perspective.
文献关键词：
中图分类号：
作者姓名：
Shaojun Zhang;Wenze Huang;Lili Ren;Xiaohui Ju;Mingli Gong;Jian Rao;Lei Sun;Pan Li;Qiang Ding;Jianwei Wang;Qiangfeng Cliff Zhang
作者机构：
MOE Key Laboratory of Bioinformatics,Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure,Center for Synthetic and Systems Biology,Tsinghua-Peking Joint Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing,China;NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory,Institute of Pathogen Biology,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China;Key Laboratory of Respiratory Disease Pathogenomics,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Center for infectious Disease Research,School of Medicine,Tsinghua University,Beijing,China
文献出处：
引用格式：
[1]Shaojun Zhang;Wenze Huang;Lili Ren;Xiaohui Ju;Mingli Gong;Jian Rao;Lei Sun;Pan Li;Qiang Ding;Jianwei Wang;Qiangfeng Cliff Zhang-.Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2)[J].细胞研究（英文版）,2022(01):9-23
A类：
interactomes,vRNAs,vRNA,ChIRP,hijacks,Cepharanthine,Trifluoperazine
B类：
Comparison,host,across,pathogenic,viruses,informs,rapid,discovery,SARS,CoV,In,contrast,extensive,research,about,interactions,that,has,revealed,major,insights,how,engage,cells,during,infection,few,studies,have,examined,between,factors,Here,profiled,three,pathogens,Zika,Ebola,using,Comparative,analyses,discovered,both,common,specific,responses,associated,proteins,variously,promote,restrict,particular,binds,IGF2BP1,stabilize,augment,translation,Our,informed,repurposing,efforts,identified,several,FDA,approved,drugs,broad,spectrum,antivirals,hACE2,transgenic,mice,treatment,comprising,was,highly,potent,against,newly,emerged,variant,Thus,our,study,illustrates,scientific,medical,utility,adopting,comparative,perspective
AB值：
0.546215
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