典型文献
Induced Dopaminergic Neurons for Parkinson's Disease Therapy:Targeting the Striatum or Midbrain/Substantia Nigra Pars Compacta?
文献摘要：
Parkinson's disease(PD)is a common neurodegenerative disease among the elderly,characterized by the specific loss of dopaminergic(DAergic)neurons in the substantia nigra pars compacta(SNpc)and defects in dopamine(DA)release in the striatum.So far,enhancement of DA concentration or electrical stimulation of specific nuclei in basal ganglia circuits is effective for the clinical treatment of PD.DA can be enhanced by either systemic drug administration or by cell-replacement treatment(CRT),and the latter is assumed to be once for all the most promising strategy for PD therapy.The cell sources for CRT include fetal mesencephalic tissue,embryonic stem cells(ESCs),and induced pluripotent stem cells(iPSCs).The alleviation of motor syndromes in PD patients and animal models following cell transplantation has been well-established[1].
文献关键词：
中图分类号：
作者姓名：
Huadong Xu;Xu Cheng;Qian Song;Yuxin Yang;Changhe Wang;Xinjiang Kang
作者机构：
Key Laboratory of Medical Electrophysiology,Ministry of Education of China,The Institute of Cardiovascular Research,Southwest Medical University,Luzhou 646000,China;Neuroscience Research Center,Institute of Mitochondrial Biology and Medicine,Key Laboratory of Biomedical Information Engineering of Ministry of Education,School of Life Science and Technology,Xi'an Jiaotong University,Xi'an 710049,China;Department of Neurology,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;College of Life Science,Liaocheng University,Liao-cheng 252059,China
文献出处：
引用格式：
[1]Huadong Xu;Xu Cheng;Qian Song;Yuxin Yang;Changhe Wang;Xinjiang Kang-.Induced Dopaminergic Neurons for Parkinson's Disease Therapy:Targeting the Striatum or Midbrain/Substantia Nigra Pars Compacta?)[J].神经科学通报（英文版）,2022(07):820-824
A类：
Dopaminergic,Striatum,Nigra,Compacta,DAergic
B类：
Induced,Neurons,Parkinson,Disease,Therapy,Targeting,Midbrain,Substantia,Pars,disease,common,neurodegenerative,among,elderly,characterized,by,specific,loss,dopaminergic,neurons,substantia,nigra,pars,compacta,SNpc,defects,release,striatum,So,far,enhancement,concentration,electrical,stimulation,nuclei,basal,ganglia,circuits,effective,clinical,treatment,can,enhanced,either,systemic,drug,administration,replacement,CRT,latter,assumed,most,promising,strategy,therapy,sources,include,fetal,mesencephalic,tissue,embryonic,cells,ESCs,induced,pluripotent,iPSCs,alleviation,motor,syndromes,patients,animal,models,following,transplantation,has,been,well,established
AB值：
0.653834
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
