典型文献
Electrophysiological Characterization of Substantia Nigra Pars Reticulata in Anesthetized Rats
文献摘要：
The substantia nigra pars reticulate(SNr),which plays a pivotal role in motor control,is the key structure in integrating information for cortex,basal ganglia and thalamus.Abnormal gait and posture deficits can be reversed by SNr deep brain stimulation(DBS)in certain Parkinson's disease cases.However,functional characterization of SNr,which is the key for the optimization of DBS effect,remains elusive.In current study,we recorded extracellular single unit in SNr of urethane anesthetized rats.We have found that urethane can induce slow delta and theta oscillations in SNr local field potential.The high gamma oscillation observed is positively correlated with the occurrence of action potential.The putative GABAergic neurons have a mean firing rate of(20.82±2.04)Hz,of which 65.2％display a regular firing pattern and 34.8％show irregular firing.Our results demonstrated the heterogeneous property of SNr and provided possible theoretical basis for promoting the next generation of DBS electrode design and optimization of clinical DBS parameters.
文献关键词：
中图分类号：
作者姓名：
LIU Xinrui;ZHANG Qianwen;WANG Ying;CHEN Fujun
作者机构：
Bio-X Institutes,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders,Ministry of Education,Shanghai Jiao Tong University,Shanghai 200240,China;Core Research Facilities,Southern University of Science and Technology,Shenzhen 518055,Guangdong,China;Exercise Health and Technology Center,Department of Physical Education,Shanghai Jiao Tong University,Shanghai 200240,China
文献出处：
引用格式：
[1]LIU Xinrui;ZHANG Qianwen;WANG Ying;CHEN Fujun-.Electrophysiological Characterization of Substantia Nigra Pars Reticulata in Anesthetized Rats)[J].上海交通大学学报（英文版）,2022(04):505-511
A类：
Electrophysiological,Nigra,Anesthetized,SNr
B类：
Characterization,Substantia,Pars,Reticulata,Rats,substantia,nigra,pars,reticulate,which,plays,pivotal,role,motor,control,key,structure,integrating,information,cortex,basal,ganglia,thalamus,Abnormal,gait,posture,deficits,can,be,reversed,by,deep,brain,stimulation,DBS,certain,Parkinson,disease,cases,However,functional,characterization,optimization,effect,remains,elusive,In,current,study,recorded,extracellular,single,unit,urethane,anesthetized,rats,We,have,found,that,induce,slow,delta,theta,oscillations,local,field,potential,high,gamma,observed,positively,correlated,occurrence,action,putative,GABAergic,neurons,mean,firing,display,pattern,show,irregular,Our,results,demonstrated,heterogeneous,property,provided,possible,theoretical,basis,promoting,next,generation,electrode,design,clinical,parameters
AB值：
0.663167
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