Objective:To evaluate the influence of different transcutaneous electrical acupoint stimulation(TEAS)modes on ovarian responses and pregnancy outcomes in patients with infertility undergoing in vitro fertilization and embryo transfer(IVF-ET).Methods:Two hundred infertility patients undergoing IVF-ET were divided randomly into experimental groups(TEAS groups:E-Ⅰ,E-Ⅱ,E-Ⅲ,and E-Ⅳ,40 cases each group)and a control group(mock TEAS group,40 patients)using the random number method.The patients in the experimental groups received TEAS treatment of 20,30,40 and 50 mA for the E-Ⅰ,E-Ⅱ,E-Ⅲ and E-Ⅳgroups,respectively.The control group received a treatment of 5 mA.TEAS was applied at acupoints of Guanyuan(RN 4),Zhongji(RN 3),Sanyinjiao(SP 6),Zigong(EX-CA 1),and Taixi(KI 13),once a day for 30 min each time for a treatment period of 10-13 d.Treatment effect was assessed using the following indicators:endometrial thickness on the 6th day of gonadotropin treatment(GN6 day),endometrial thickness on the day on chorionic gonadotropin administration(HCG day),number of ovarian follicles on HCG day,number of ova captured,amount of estrogen required for each harvested ova,number of mature ova divided by the total number of ova,percentage of high-quality embryos,and clinical pregnancy.Results:Endometrial thickness in the experimental groups on the HCG day was significantly better than that of the control group after TEAS stimulation(P=0.01).TEAS exhibited a greater impact on the number of ova captured(P=0.003).However,the effect of TEAS stimulation on the high-quality embryo rate and clinical pregnancy in patients was not statistically significant(P＞0.05).Conclusions:TEAS is an effective method in improving the ovarian state.When the stimulus intensity was at 40 mA and above,it could be helpful to improve the patient's endometrial condition and endometrial receptivity and to retrieve more oocytes.

ZHAI Zhi-jin;LIU Jia-en;LEI Ling-ling;WANG Shu-yu

Department of Reproductive Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital,Beijing,100026,China;Center for Reproductive Medicine,Beijing Jia-En De Yun Hospital,Beijing,100089,China

中国结合医学杂志（英文版）

[1]ZHAI Zhi-jin;LIU Jia-en;LEI Ling-ling;WANG Shu-yu-.Effects of Transcutaneous Electrical Acupoint Stimulation on Ovarian Responses and Pregnancy Outcomes in Patients Undergoing IVF-ET:A Randomized Controlled Trial)[J].中国结合医学杂志（英文版）,2022(05):434-439

Guanyuan,Zhongji,Zigong,GN6

Effects,Transcutaneous,Electrical,Acupoint,Stimulation,Ovarian,Responses,Pregnancy,Outcomes,Patients,Undergoing,IVF,ET,Randomized,Controlled,Trial,Objective,To,evaluate,influence,different,transcutaneous,electrical,stimulation,TEAS,modes,ovarian,responses,pregnancy,outcomes,patients,infertility,undergoing,vitro,fertilization,transfer,Methods,Two,hundred,were,divided,randomly,into,experimental,groups,cases,each,control,mock,using,number,method,received,treatment,mA,respectively,was,applied,acupoints,RN,Sanyinjiao,SP,EX,CA,Taixi,KI,once,day,period,Treatment,assessed,following,indicators,endometrial,thickness,6th,gonadotropin,chorionic,administration,HCG,follicles,captured,amount,estrogen,required,harvested,mature,by,total,percentage,high,quality,embryos,clinical,Results,Endometrial,significantly,better,than,that,after,exhibited,greater,impact,However,rate,not,statistically,Conclusions,effective,improving,state,When,stimulus,intensity,above,could,helpful,improve,condition,receptivity,retrieve,more,oocytes

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