Chronic diseases comprise a wide range of abnormal conditions and illnesses that impair patients'physical and/or mental function-ing,and last for a long time.Largely a contemporary plague,chronic diseases are responsible for the observed morbidity and mortality in developed countries as well as in some developing countries[1,2].These disabling and deadly diseases range from cardiovascular and cerebrovascular diseases and metabolic disor-ders such as obesity,diabetes,and metabolic syndrome,to degen-erative neurological disorders such as Parkinson's disease and Alzheimer's disease.They are characterized by multifactorial pathogenesis with associated specific symptoms,whose progres-sion may be somehow delayed or alleviated through medical treatment and/or lifestyle changes.The biochemical abnormalities associated with these diseases,such as high blood glucose in diabetes mellitus,high blood cholesterol in cardiovascular dis-eases,and high liver fat content in fatty liver diseases,represent the biological phenotype connected with clinical manifestation(symptoms or signs).Although genetic background,unhealthy life-style,food,and environmental factors have been reported to play a role in the pathogenesis of chronic diseases,the underlying root causes of most of these chronic diseases remain elusive.

Bin Hong;Jian-Dong Jiang

NHC Key Laboratory of Biotechnology of Antibiotics,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China;CAMS Key Laboratory of Synthetic Biology for Drug Innovation,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China

工程（英文）

[1]Bin Hong;Jian-Dong Jiang-.Treating Chronic Diseases by Regulating the Gut Microbiota)[J].工程（英文）,2022(11):17-20

Treating,Chronic,Diseases,by,Regulating,Gut,Microbiota,diseases,comprise,wide,range,conditions,illnesses,that,impair,patients,physical,function,last,long,Largely,contemporary,plague,chronic,are,responsible,observed,morbidity,mortality,developed,countries,well,developing,These,disabling,deadly,from,cardiovascular,cerebrovascular,metabolic,such,obesity,diabetes,syndrome,degen,erative,neurological,disorders,Parkinson,Alzheimer,They,characterized,multifactorial,pathogenesis,associated,specific,symptoms,whose,progres,sion,may,somehow,delayed,alleviated,through,medical,treatment,lifestyle,changes,biochemical,abnormalities,these,high,blood,glucose,mellitus,cholesterol,liver,content,fatty,represent,biological,phenotype,connected,clinical,manifestation,signs,Although,genetic,background,unhealthy,food,environmental,factors,have,been,reported,play,role,underlying,root,causes,most,remain,elusive

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