典型文献
Efficacy of Wen-Luo-Tong on Peripheral Neuropathy Induced by Chemotherapy or Target Therapy:A Randomized,Double-Blinded,Placebo-Controlled Trial
文献摘要：
Objective:To evaluate the efficacy of Wen-Luo-Tong Granules(WLT)local administration in the treatment of patients with peripheral neuropathy(PN)induced by chemotherapy or target therapy.Methods:This study is a randomized,double-blinded,and placebo-controlled trial.Seventy-eight patients with PN induced by chemotherapy or target therapy were enrolled from China-Japan Friendship Hospital between July 2019 and January 2020.They were randomly assigned to WLT(39 cases)and control groups(39 cases)using a block randomization method.The WLT group received WLT(hand and foot bath)plus oral Mecobalamin for 1 week,while the control group received placebo plus oral Mecobalamin.The primary endpoint was PN grade evaluated by the National Cancer Institute-Common Toxicity Criteria for Adverse Events(NCI-CTCAE).The secondary endpoints included quantitative touch-detection threshold,neuropathy symptoms,Quality of Life Questionnaire-Chemotherapy Induced Peripheral Neuropathy(QLQ-CIPN20),and Quality of Life Questionnaire-Core30(QLQ-C30).Results:After treatment,the PN grade in the WLT group was significantly lower than that in the control group(1.00±0.29 vs.1.75±0.68,P＜0.01).The total effective rate in the WLT group was significantly higher than that in the control group(82.05％vs.51.28％,P＜0.01).Compared with the control group,the touch-detection thresholds at fingertips,neuropathy symptom score,QLQ-CIPN 20(sensory scale,motor scale,autonomic scale,and sum score),and QLQ-C30(physical functioning,role functioning,emotional functioning,and global health)in the WLT group significantly improved after treatment(P＜0.01 or P＜0.05).Conclusion:WLT local administration was significantly effective in the treatment of patients with PN induced by chemotherapy or target therapy.
文献关键词：
中图分类号：
作者姓名：
DENG Bo;JIA Li-qun;WAN Dong-gui;WANG Bao-yi;CHENG Zhi-qiang;DENG Chao
作者机构：
Center of Science and Technology,China-Japan Friendship Hospital,Beijing,100029,China;Integrative Oncology Department of Chinese Medicine and Western Medicine,China-Japan Friendship Hospital,Beijing,100029,China
文献出处：
引用格式：
[1]DENG Bo;JIA Li-qun;WAN Dong-gui;WANG Bao-yi;CHENG Zhi-qiang;DENG Chao-.Efficacy of Wen-Luo-Tong on Peripheral Neuropathy Induced by Chemotherapy or Target Therapy:A Randomized,Double-Blinded,Placebo-Controlled Trial)[J].中国结合医学杂志（英文版）,2022(07):579-585
A类：
Blinded,WLT,Mecobalamin,CIPN20,Core30
B类：
Efficacy,Wen,Luo,Tong,Peripheral,Neuropathy,Induced,by,Chemotherapy,Target,Therapy,Randomized,Double,Placebo,Controlled,Trial,Objective,efficacy,Granules,local,administration,treatment,patients,peripheral,neuropathy,induced,chemotherapy,target,Methods,This,study,randomized,double,blinded,placebo,controlled,trial,Seventy,eight,were,enrolled,from,China,Japan,Friendship,Hospital,between,July,January,They,randomly,assigned,cases,groups,using,block,randomization,method,received,hand,foot,bath,plus,oral,week,while,primary,was,grade,evaluated,National,Cancer,Institute,Common,Toxicity,Criteria,Adverse,Events,NCI,CTCAE,secondary,endpoints,included,quantitative,touch,detection,symptoms,Quality,Life,Questionnaire,QLQ,C30,Results,After,significantly,lower,than,that,total,effective,rate,higher,Compared,thresholds,fingertips,score,sensory,scale,motor,autonomic,sum,physical,functioning,role,emotional,global,health,improved,after,Conclusion
AB值：
0.491686
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