典型文献
Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage
文献摘要：
Alzheimer's disease(AD)is one of the most common neurodegenerative diseases among the elderly and it accounts for nearly 80％of all dementias.The pathogenesis of AD is complicated and enigmatic thus far.The mitochondrial cascade hypothesis assumes that mitochondrial damage may mediate,drive,or contribute to a variety of AD pathologies and may be the main factor in late-onset AD.Currently,there are no widely recognized drugs able to attenuate mitochondrial damage in AD.Notably,increasing evidence supports the efficacy of acupuncture for improving the mitochondrial structure and protecting mitochondrial functions in AD.This review reports the mechanisms by which acupuncture regulates mitochondrial dynamics,energy metabolism,calcium homeostasis and apoptosis.In conclusion,these findings suggest that AD mitochondrial dysfunction represents a reasonable therapeutic target and acupuncture could play a significant role in preventing and treating AD.
文献关键词：
中图分类号：
作者姓名：
JIANG Yu-hang;HE Jia-kai;LI Ran;CHEN Ze-hao;JIA Bao-hui
作者机构：
Department of Acupuncture,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China
文献出处：
引用格式：
[1]JIANG Yu-hang;HE Jia-kai;LI Ran;CHEN Ze-hao;JIA Bao-hui-.Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage)[J].中国结合医学杂志（英文版）,2022(03):272-280
A类：
dementias
B类：
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AB值：
0.69356
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