典型文献
The miR-23-27-24 cluster:an emerging target in NAFLD pathogenesis
文献摘要：
The incidence of non-alcoholic fatty liver disease(NAFLD)is increasing globally,being the most widespread form of chronic liver disease in the west.NAFLD includes a variety of disease states,the mildest being non-alcoholic fatty liver that gradually progresses to non-alcoholic steatohepatitis,fibrosis,cirrhosis,and eventually hepatocellular carcinoma.Small non-coding single-stranded microRNAs(miRNAs)regulate gene expression at the miRNA or translational level.Numerous miRNAs have been shown to promote NAFLD pathogenesis and progression through increasing lipid accumulation,oxidative stress,mitochondrial damage,and inflammation.The miR-23-27-24 clusters,composed of miR-23a-27a-24-2 and miR-23b-27b-24-1,have been implicated in various biological processes as well as many diseases.Herein,we review the current knowledge on miR-27,miR-24,and miR-23 in NAFLD pathogenesis and discuss their potential significance in NAFLD diagnosis and therapy.
文献关键词：
中图分类号：
作者姓名：
Lin Ru;Xiao-mei Wang;Jun-qi Niu
作者机构：
Department of Hepatology,The First Hospital of Jilin University,Changchun 130021,China;Key Laboratory of Zoonosis Research,Ministry of Education,The First Hospital of Jilin University,Changchun 130021,China
文献出处：
引用格式：
[1]Lin Ru;Xiao-mei Wang;Jun-qi Niu-.The miR-23-27-24 cluster:an emerging target in NAFLD pathogenesis)[J].中国药理学报（英文版）,2022(05):1167-1179
A类：
mildest
B类：
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AB值：
0.621402
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