典型文献
Hepatic hormone FGF21 and its analogues in clinical trials
文献摘要：
Fibroblast growth factor 21 (FGF21) is a fasting or stress inducible metabolic hormone produced mainly in the liver. It plays important roles in regulating both glucose and lipid homeostasis via interacting with a heterodimeric receptor complex comprising FGF receptor 1 (FGFR1) and β-klotho (KLB). For the past decade, great effort has been made on developing FGF21 derivatives or specific FGF21 receptor agonists into therapeutic agents for various metabolic disorders including type 2 diabetes (T2D), obesity, and more importantly, nonalcoholic fatty liver disease (NAFLD). Here we have reviewed FGF21 gene and protein structures, its expression pattern, cellular signaling cascades that mediate FGF21 production and function. We have then summarized the six clinical trials utilizing four FGF21 analogues. Finally, two recent literatures on the development of GLP-1 and FGF21 dual agonists were presented briefly.
文献关键词：
dual agonists;fibroblast growth factor 21;lipid metabolism;metabolic diseases
中图分类号：
作者姓名：
Shao Weijuan;Jin Tianru
作者机构：
Division of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada;Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;Banting and Best Diabetes Center, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
文献出处：
引用格式：
[1]Shao Weijuan;Jin Tianru-.Hepatic hormone FGF21 and its analogues in clinical trials)[J].慢性疾病与转化医学（英文）,2022(01):19-25
A类：
KLB
B类：
Hepatic,hormone,FGF21,its,analogues,clinical,trials,Fibroblast,growth,fasting,stress,inducible,metabolic,produced,mainly,liver,It,plays,roles,regulating,both,glucose,lipid,homeostasis,via,interacting,heterodimeric,receptor,complex,comprising,FGFR1,klotho,For,past,decade,great,effort,has,been,made,developing,derivatives,specific,agonists,into,therapeutic,agents,various,disorders,including,type,diabetes,T2D,obesity,more,importantly,nonalcoholic,fatty,NAFLD,Here,have,reviewed,gene,protein,structures,expression,pattern,cellular,signaling,cascades,that,mediate,production,function,We,then,summarized,six,utilizing,four,Finally,two,recent,literatures,development,GLP,dual,were,presented,briefly,fibroblast,metabolism,diseases
AB值：
0.683425
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
