典型文献
Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver
文献摘要：
Dear Editor,
The sodium taurocholate(TC)co-transporting polypeptide NTCP(SLC10A1)is a secondary active membrane transport protein that mediates the uptake of bile salts from the portal blood plasma into the cytoplasm of liver cells.NTCP was originally cloned from rat and demonstrated to be localized in the basolateral membrane.1 Its activity is a key component of bile acid homeostasis and enterohepatic circulation of bile salts(Fig.1a),a process that includes at least three additional transporter proteins,namely BSEP,ASBT and OSTα/β.2,3 In addition to its role in mediating bile salt uptake,NTCP also serves as the receptor of the human hepatitis B and D viruses.4 The mechanism by which NTCP recognizes and transports bile salts is not understood,in part because no structural insight into the interaction of NTCP with its substrates is available.While recent studies reported structures of NTCP bound to inhibitory nanobodies5 or Fab fragments,6,7 no substrate-binding pockets were identified.
文献关键词：
中图分类号：
作者姓名：
Hongtao Liu;Rossitza N.Irobalieva;Rose Bang-S?rensen;Kamil Nosol;Somnath Mukherjee;Parth Agrawal;Bruno Stieger;Anthony A.Kossiakoff;Kaspar P.Locher
作者机构：
Institute of Molecular Biology and Biophysics,ETH Zürich,Zürich,Switzerland;Department of Biochemistry and Molecular Biology,University of Chicago,Chicago,IL,USA;Department of Clinical Pharmacology and Toxicology,University Hospital Zürich,University of Zürich,Zürich,Switzerland
文献出处：
引用格式：
[1]Hongtao Liu;Rossitza N.Irobalieva;Rose Bang-S?rensen;Kamil Nosol;Somnath Mukherjee;Parth Agrawal;Bruno Stieger;Anthony A.Kossiakoff;Kaspar P.Locher-.Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver)[J].细胞研究（英文版）,2022(08):773-776
A类：
ASBT,nanobodies5
B类：
Structure,human,NTCP,reveals,basis,recognition,sodium,driven,bile,salts,into,liver,Dear,Editor,
The,taurocholate,transporting,polypeptide,SLC10A1,secondary,active,membrane,that,mediates,uptake,from,portal,blood,plasma,cytoplasm,cells,was,originally,cloned,demonstrated,localized,basolateral,Its,activity,key,component,acid,homeostasis,enterohepatic,circulation,Fig,1a,process,includes,least,three,additional,transporter,proteins,namely,BSEP,OST,In,its,role,mediating,also,serves,receptor,hepatitis,viruses,mechanism,by,which,recognizes,transports,not,understood,part,because,structural,insight,interaction,substrates,available,While,recent,studies,reported,structures,bound,inhibitory,Fab,fragments,binding,pockets,were,identified
AB值：
0.616879
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
