典型文献
The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication
文献摘要：
Rice stripe virus(RSV)transmitted by the small brown planthopper causes severe rice yield losses in Asian countries.Although viral nuclear entry promotes viral replication in host cells,whether this phenomenon occurs in vector cells remains unknown.Therefore,in this study,we systematically evaluated the presence and roles of RSV in the nuclei of vector insect cells.We observed that the nucleocapsid protein(NP)and viral genomic RNAs were partially transported into vector cell nuclei by utilizing the importin a nuclear transport sys-tem.When blocking NP nuclear localization,cytoplas-mic RSV accumulation significantly increased.In the vector cell nuclei,NP bound the transcription factor YY1 and affected its positive regulation to FAIM.Subse-quently,decreased FAIM expression triggered an antiviral caspase-dependent apoptotic reaction.Our results reveal that viral nuclear entry induces com-pletely different immune effects in vector and host cells,providing new insights into the balance between viral load and the immunity pressure in vector insects.
文献关键词：
中图分类号：
作者姓名：
Wan Zhao;Junjie Zhu;Hong Lu;Jiaming Zhu;Fei Jiang;Wei Wang;Lan Luo;Le Kang;Feng Cui
作者机构：
State Key Laboratory of Integrated Management of Pest Insects and Rodents,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;CAS Center for Excellence in Biotic Interactions,University of Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]Wan Zhao;Junjie Zhu;Hong Lu;Jiaming Zhu;Fei Jiang;Wei Wang;Lan Luo;Le Kang;Feng Cui-.The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication)[J].蛋白质与细胞,2022(05):360-378
A类：
importin,cytoplas,FAIM
B类：
nucleocapsid,protein,rice,stripe,virus,nuclei,vector,regulates,replication,Rice,RSV,transmitted,by,small,brown,planthopper,causes,severe,yield,losses,Asian,countries,Although,nuclear,entry,promotes,host,cells,whether,this,phenomenon,occurs,remains,unknown,Therefore,study,systematically,evaluated,presence,roles,We,observed,that,NP,genomic,RNAs,were,partially,transported,into,utilizing,When,blocking,localization,accumulation,significantly,increased,In,bound,transcription,YY1,affected,its,positive,regulation,Subse,quently,decreased,expression,triggered,antiviral,caspase,dependent,apoptotic,reaction,Our,results,reveal,induces,com,pletely,different,immune,effects,providing,new,insights,balance,between,load,immunity,pressure,insects
AB值：
0.581521
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