典型文献
An in situ nanoparticle recombinant strategy for the enhancement of photothermal therapy
文献摘要：
Photothermal therapy (PTr)-induced immune response has attracted much attention,however,which cannot work at full capacity.In this study,the simvastatin (SV) adjuvant is loaded into gold nanocages(AuNCs) to develop a simple drug delivery system,which can efficiently utilize the tumor-associated antigens (TAAs) for improving immune responses.AuNCs/SV-mediated PTT treatment enhances tumor cells damage and promotes the release of TAAs which are immediately captured by AuNCs/SV to form AuNCs/SV/TAAs recombinant nanoparticle.Impressively,AuNCs/SV/TAAs can accumulate in lymph nodes effectively due to the suitable size of～55 nm and hyperthermia-induced vasodilative effect.And the co-delivery of antigen and adjuvant is beneficial to stimulating the maturation of dendritic cells for further activating T cells.In a word,the recombinant strategy could make full use of TAAs to produce an indi-vidual powerful immunotherapy.
文献关键词：
中图分类号：
作者姓名：
Xinxin Liu;Cuixia Zheng;Yueyue Kong;Hao Wang;Lei Wang
作者机构：
Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 47100g,China;School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China;Key Laboratory of Advanced Drug Preparation Technologies,Ministry of Education,School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China;Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases,Zhengzhou University,Zhengzhou 450001,China;Tumor Immunity and Biomaterials Advanced Medical Center,Zhengzhou University,Luoyang 471009,China
文献出处：
引用格式：
[1]Xinxin Liu;Cuixia Zheng;Yueyue Kong;Hao Wang;Lei Wang-.An in situ nanoparticle recombinant strategy for the enhancement of photothermal therapy)[J].中国化学快报（英文版）,2022(01):328-333
A类：
PTr,TAAs,vasodilative
B类：
situ,nanoparticle,recombinant,strategy,enhancement,photothermal,Photothermal,induced,immune,has,attracted,much,attention,however,which,cannot,work,full,capacity,In,this,study,simvastatin,SV,adjuvant,loaded,into,gold,nanocages,AuNCs,develop,simple,drug,delivery,system,efficiently,utilize,tumor,associated,antigens,improving,responses,mediated,PTT,treatment,enhances,cells,damage,promotes,release,are,immediately,captured,by,form,Impressively,accumulate,lymph,nodes,effectively,due,suitable,size,hyperthermia,And,beneficial,stimulating,maturation,dendritic,further,activating,word,could,make,use,produce,indi,vidual,powerful,immunotherapy
AB值：
0.579762
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