典型文献
Histological assessment based on liver biopsy:the value and challenges in NASH drug development
文献摘要：
Nonalcoholic steatohepatitis(NASH)is increasingly recognized as a serious disease that can lead to cirrhosis,hepatocellular carcinoma(HCC),and death.However,there is no effective drug to thwart the progression of the disease.Development of new drugs for NASH is an urgent clinical need.Liver biopsy plays a key role in the development of new NASH drugs.Histological findings based on liver biopsy are currently used as the main inclusion criteria and the primary therapeutic endpoint in NASH clinical trials.However,there are inherent challenges in the use of liver biopsy in clinical trials,such as evaluation reliability,sampling error,and invasive nature of the procedure.In this article,we review the advantages and value of liver histopathology based on liver biopsy in clinical trials of new NASH drugs.We also discuss the challenges and limitations of liver biopsy and identify future drug development directions.
文献关键词：
中图分类号：
作者姓名：
Xiao-fei Tong;Qian-yi Wang;Xin-yan Zhao;Ya-meng Sun;Xiao-ning Wu;Li-ling Yang;Zheng-zhao Lu;Xiao-juan Ou;Ji-dong Jia;Hong You
作者机构：
Liver Research Center,Beijing Friendship Hospital,Capital Medical University,Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis,National Clinical Research Center of Digestive Diseases,Beijing 100050,China
文献出处：
引用格式：
[1]Xiao-fei Tong;Qian-yi Wang;Xin-yan Zhao;Ya-meng Sun;Xiao-ning Wu;Li-ling Yang;Zheng-zhao Lu;Xiao-juan Ou;Ji-dong Jia;Hong You-.Histological assessment based on liver biopsy:the value and challenges in NASH drug development)[J].中国药理学报（英文版）,2022(05):1200-1209
A类：
thwart
B类：
Histological,assessment,liver,biopsy,value,challenges,NASH,development,Nonalcoholic,steatohepatitis,increasingly,recognized,serious,disease,that,can,lead,cirrhosis,hepatocellular,carcinoma,HCC,death,However,there,effective,progression,Development,new,drugs,urgent,clinical,need,Liver,plays,key,role,findings,are,currently,used,main,inclusion,criteria,primary,therapeutic,endpoint,trials,inherent,such,evaluation,reliability,sampling,error,invasive,nature,procedure,In,this,article,review,advantages,histopathology,We,also,discuss,limitations,identify,future,directions
AB值：
0.51035
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