典型文献
A gut feeling:diet-sensing mesenchymal cells regulate intestinal stem cell function
文献摘要：
Due to its remarkable regenerative capacity,the intestine and particularly intestinal stem cells(ISCs),have become a popular model for studying homeostasis,regeneration,and oncogenic transformation of adult mammalian tissues.In a recent paper published in Cell Research,Deng et al.report that Leptin receptor-positive mesenchymal cells surrounding intestinal crypts sense diet alterations and modulate ISC function via a stromal IGF1-epithelial IGF1R axis.
Maintenance of the physiological functions of the gut epithelium,including preservation of barrier integrity,nutrient absorption,and hormonal regulation,is highly dependent on the self-renewal capacity of intestinal stem cells(ISCs).
文献关键词：
中图分类号：
作者姓名：
Julia Messina-Pacheco;Alex Gregorieff
作者机构：
Department of Pathology,McGill University,Montreal,QC,Canada;Cancer Research Program,Research Institute of the McGill University Health Centre,Montreal,QC,Canada;McGill Regenerative Medicine Network,McGill University,Montreal,QC,Canada
文献出处：
引用格式：
[1]Julia Messina-Pacheco;Alex Gregorieff-.A gut feeling:diet-sensing mesenchymal cells regulate intestinal stem cell function)[J].细胞研究（英文版）,2022(07):605-606
A类：
Maintenance
B类：
gut,feeling,diet,sensing,mesenchymal,cells,regulate,intestinal,stem,Due,its,remarkable,regenerative,capacity,intestine,particularly,ISCs,have,become,popular,model,studying,homeostasis,regeneration,oncogenic,transformation,adult,mammalian,tissues,In,recent,paper,published,Cell,Research,Deng,report,that,Leptin,receptor,positive,surrounding,crypts,sense,alterations,modulate,via,stromal,epithelial,IGF1R,axis,physiological,functions,epithelium,including,preservation,barrier,integrity,nutrient,absorption,hormonal,regulation,highly,dependent,self,renewal
AB值：
0.707659
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
