典型文献
Docosahexaenoic acid-rich fi sh oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice
文献摘要：
It is unclear how docosahexaenoic acid (DHA) improves insulin resistance via modulating gut microbiome in obese individuals. We used diet-induced obesity (DIO) mice as a model to study the effects of DHA-rich fish oil (DHA-FO) on host metabolic disorders and colonic microbiome. DHA-FO reduced fat deposition, regulated lipid profiles and alleviated insulin resistance in DIO mice. Probably because DHA-FO prevented the permeation of lipopolysaccharide across intestinal epithelial barrier, and promoted peptide YY (PYY) secretion via the mediation of short chain fatty acids receptor (FFAR2) in colon. Furthermore, DHA-FO might regulate PYY expression by reversing microbial dysbiosis, including increasing the abundance of Akkermansia muciniphila and Lactobacillus, and suppressing the growth of Helicobacter. DHA-FO also altered gut microbial function (e.g. "linoleic acid metabolism") associated with PYY expression (r > 0.80, P < 0.05). Herein, DHA-FO enhanced insulin action on glucose metabolism by altering gut microbiome and facilitating colonic PYY expression in DIO mice.
文献关键词：
中图分类号：
作者姓名：
Wanxiu Cao;Fang Liu;Robert W.Li;Yaoxian Chin;Yuming Wang;Changhu Xue;Qingjuan Tang
作者机构：
College of Food Science and Engineering,Ocean University of China,Qingdao 266003,China;Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;United States Department of Agriculture,Agriculture Research Service(USDA-ARS),Animal Genomics and Improvement Laboratory,Beltsville,MD 20705,USA;Hainan Tropical Ocean University,Sanya 572022,China;Laboratory for Marine Drugs and Bioproducts,Qingdao National Laboratory for Marine Science and Technology,Qingdao 266003,China
文献出处：
引用格式：
[1]Wanxiu Cao;Fang Liu;Robert W.Li;Yaoxian Chin;Yuming Wang;Changhu Xue;Qingjuan Tang-.Docosahexaenoic acid-rich fi sh oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice)[J].食品科学与人类健康（英文）,2022(01):177-188
A类：
Docosahexaenoic,Probably
B类：
rich,oil,prevented,insulin,resistance,by,modulating,gut,microbiome,promoting,colonic,peptide,expression,diet,induced,obesity,mice,It,unclear,how,docosahexaenoic,DHA,improves,obese,individuals,We,used,DIO,model,study,effects,fish,FO,host,metabolic,disorders,reduced,deposition,regulated,lipid,profiles,alleviated,because,permeation,lipopolysaccharide,across,intestinal,epithelial,barrier,promoted,PYY,secretion,mediation,short,chain,fatty,acids,receptor,FFAR2,Furthermore,might,reversing,microbial,dysbiosis,including,increasing,abundance,Akkermansia,muciniphila,Lactobacillus,suppressing,growth,Helicobacter,also,altered,function,linoleic,metabolism,associated,Herein,enhanced,action,glucose,altering,facilitating
AB值：
0.51886
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
