典型文献
Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice
文献摘要：
SARS-CoV-2 infection is a global public health threat.Vaccines are considered amongst the most important tools to control the SARS-CoV-2 pandemic.As expected,deaths from SARS-CoV-2 infection have dropped dramatically with widespread vaccination.However,there are concerns over the duration of vaccine-induced protection,as well as their effectiveness against emerging variants of concern.Here,we constructed a recombinant chimpanzee adenovirus vectored vaccine expressing the full-length spike of SARS-CoV-2(AdC68-S).Rapid and high levels of humoral and cellular immune responses were observed after immunization of C57BL/6J mice with one or two doses of AdC68-S.Notably,neutralizing antibodies were observed up to at least six months after vaccination,without substantial decline.Single or double doses AdC68-S immunization resulted in lower viral loads in lungs of mice against SARS-CoV-2 challenge both in the short term(21 days)and long-term(6 months).Histopathological examination of AdC68-S immunized mice lungs showed mild histological abnormalities after SARS-CoV-2 infection.Taken together,this study demonstrates the efficacy and durability of the AdC68-S vaccine and con-stitutes a promising candidate for clinical evaluation.
文献关键词：
中图分类号：
作者姓名：
Mingqing Lu;Kunpeng Liu;Yun Peng;Zhe Ding;Yingwen Li;Alexander Tendu;Xue Hu;Ge Gao;Weiwei Guo;Hang Liu;Juhong Rao;Jiaxuan Zhao;Miaoyu Chen;Zhiming Yuan;Gary Wong;Chao Shan;Yanfeng Yao;Jiaming Lan
作者机构：
CAS Key Laboratory of Molecular Virology&Immunology,Institut Pasteur of Shanghai,Chinese Academy of Sciences,Shanghai,200031,China;State Key Laboratory of Virology,Chinese Academy of Sciences,Wuhan,430071,China;University of Chinese Academy of Sciences,Beijing,100049,China;Center for Biosafety Mega-Science,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,430071,China
文献出处：
引用格式：
[1]Mingqing Lu;Kunpeng Liu;Yun Peng;Zhe Ding;Yingwen Li;Alexander Tendu;Xue Hu;Ge Gao;Weiwei Guo;Hang Liu;Juhong Rao;Jiaxuan Zhao;Miaoyu Chen;Zhiming Yuan;Gary Wong;Chao Shan;Yanfeng Yao;Jiaming Lan-.Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice)[J].中国病毒学,2022(04):581-590
A类：
chimpanzee,AdC68,stitutes
B类：
Recombinant,adenovirus,vaccine,expressing,spike,protein,provides,lasting,protection,against,SARS,CoV,infection,mice,global,public,health,threat,Vaccines,are,considered,amongst,most,important,tools,control,pandemic,expected,deaths,from,have,dropped,dramatically,widespread,vaccination,However,there,concerns,over,duration,induced,well,their,effectiveness,emerging,variants,Here,constructed,recombinant,vectored,full,length,Rapid,high,levels,humoral,cellular,immune,responses,were,observed,after,immunization,C57BL,6J,one,two,doses,Notably,neutralizing,antibodies,up,least,six,months,without,substantial,decline,Single,double,resulted,lower,viral,loads,lungs,challenge,both,short,term,days,long,Histopathological,examination,immunized,showed,mild,histological,abnormalities,Taken,together,this,study,demonstrates,efficacy,durability,promising,candidate,clinical,evaluation
AB值：
0.588049
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
