典型文献
A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state
文献摘要：
Dopamine (DA) level inthe nucleus accumbens (NAc) is critical for reward and aversion encoding.DA released from the ventral mesencephalon (VM) DAergic neurons increases the excitability of VM-projecting D1-dopamine receptor-expressing medium spiny neurons (D1-MSNs) in the NAc to enhance DA release and augment rewards.However,how such a DA positive feedback loop is regulated to maintain DA homeostasis and reward-averSion balance remains elusive.Here we report that the ventral pallidum (VP)projection of NAc D1-MSNs (D1NAc-VP) is inhibited by rewarding st muli and activated by averslVe stimuli.In contrast to the VM projection of D1-MSN (D1NAc-VM),activation ofD1 NAc-VP projection induces aversion,but not reward.D1NAc-VP MSNs are distinct from the D1NAc-VM MSNs,which exhibit conventional functions of D1-MSNs.Activation of D1NAc-VP projection stimulates VM GABAergic transmission,inhibits VM DAergic neurons,and reduces DA release into the NAc.Thus,D1NAc-VP and D1NAc-VM MSNs cooperatively control NAc dopamine balance and reward-aversion states.
文献关键词：
中图分类号：
作者姓名：
Zhiyuan Liu;Qiumin Le;Yanbo Lv;Xi Chen;Jian Cui;Yiming Zhou;Deqin Cheng;Chaonan Ma;Xiujuan Su;Lei Xiao;Ruyi Yang;Jiayi Zhang;Lan Ma;Xing Liu
作者机构：
Department of Neurosurgery,Huashan Hospital,School of Basic Medical Sciences,and Institutes of Brain Science,State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Fudan University,Shanghai,China
文献出处：
引用格式：
[1]Zhiyuan Liu;Qiumin Le;Yanbo Lv;Xi Chen;Jian Cui;Yiming Zhou;Deqin Cheng;Chaonan Ma;Xiujuan Su;Lei Xiao;Ruyi Yang;Jiayi Zhang;Lan Ma;Xing Liu-.A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state)[J].细胞研究（英文版）,2022(02):139-156
A类：
mesencephalon,DAergic,averSion,D1NAc,muli,averslVe,ofD1
B类：
distinct,subpopulation,down,regulates,dopamine,promote,negative,emotional,Dopamine,level,inthe,nucleus,accumbens,critical,aversion,encoding,released,from,ventral,VM,neurons,increases,excitability,projecting,receptor,expressing,medium,spiny,MSNs,enhance,augment,rewards,However,how,such,positive,feedback,loop,regulated,maintain,homeostasis,balance,remains,elusive,Here,report,that,pallidum,VP,projection,inhibited,by,rewarding,activated,stimuli,In,contrast,activation,induces,but,not,are,which,exhibit,conventional,functions,Activation,stimulates,GABAergic,transmission,inhibits,reduces,into,Thus,cooperatively,control,states
AB值：
0.437056
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
