典型文献
Antidepressant-like effects of cinnamamide derivative M2 via D2 receptors in the mouse medial prefrontal cortex
文献摘要：
Major depressive disorder is a global mental illness associated with severe mortality and disability.The dopaminergic system is involved in both the etiology and therapeutics of depression.Distinct functions of dopamine D1 and D2 receptor subtypes have attracted considerable research interest,and their roles in the pathogenesis of depression and interaction with antidepressants need to be comprehensively elucidated.Herein,we investigated the antidepressant effects of a candidate antidepressant from a cinnamamide derivative,M2,and examined underlying neural mechanisms.We observed that a single dose of M2(30 mg/kg,ip)produced rapid antidepressant-like effects in mice subjected to the forced swim and tail suspension tests.Using whole-cell recordings in mouse coronal brain slices,we found that application of M2(10-150 μM)concentration-dependently increased the frequency of spontaneous excitatory postsynaptic currents(sEPSCs)of the pyramidal neurons in the medial prefrontal cortex(mPFC).Furthermore,M2-induced enhancement of sEPSC frequency was abolished by sulpiride(10μM),a dopamine D2 receptor antagonist,but not by the dopamine receptor D,antagonist,SCH23390(10 μM).In addition,M2 administration significantly increased expression levels of synaptogenesis-related proteins,including p-mTOR and p-TrkB,in the mPFC at 30 min,and increased postsynaptic protein PSD-95 at 24 h.Our results demonstrated that M2 produces rapid antidepressant actions through a novel mechanism via dopamine D2 receptor-mediated enhancement of mPFC neurotransmission.
文献关键词：
中图分类号：
作者姓名：
Yan-xin Che;Xiao-yan Jin;Rong-hua Xiao;Ming Zhang;Xiao-hui Ma;Fei Guo;Yang Li
作者机构：
Schoolof Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing 210023,China;CAS Key Laboratory of Receptor Research,Center for Neurological and Psychiatric Research and Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China;State Key Laboratory of Core Technology in Innovative Chinese Medicine,Tasly Pharmaceutical Group Co.,Ltd.,Tianjin 300410,China
文献出处：
引用格式：
[1]Yan-xin Che;Xiao-yan Jin;Rong-hua Xiao;Ming Zhang;Xiao-hui Ma;Fei Guo;Yang Li-.Antidepressant-like effects of cinnamamide derivative M2 via D2 receptors in the mouse medial prefrontal cortex)[J].中国药理学报（英文版）,2022(09):2267-2275
A类：
cinnamamide,sEPSCs,sEPSC,sulpiride,SCH23390,synaptogenesis,neurotransmission
B类：
Antidepressant,like,effects,derivative,M2,via,D2,receptors,mouse,medial,prefrontal,cortex,Major,depressive,disorder,global,mental,illness,associated,severe,mortality,disability,dopaminergic,system,involved,both,etiology,therapeutics,depression,Distinct,functions,D1,subtypes,have,attracted,considerable,research,interest,their,roles,pathogenesis,interaction,antidepressants,need,be,comprehensively,elucidated,Herein,we,investigated,candidate,from,examined,underlying,neural,mechanisms,We,observed,that,single,dose,ip,produced,rapid,mice,subjected,forced,swim,tail,suspension,tests,Using,whole,cell,recordings,coronal,brain,slices,found,application,concentration,dependently,increased,frequency,spontaneous,excitatory,postsynaptic,currents,pyramidal,neurons,mPFC,Furthermore,induced,enhancement,was,abolished,by,antagonist,but,not,In,addition,administration,significantly,expression,levels,related,proteins,including,mTOR,TrkB,PSD,Our,results,demonstrated,produces,actions,through,novel,mediated
AB值：
0.594849
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
