典型文献
Age-dependent alterations in key components of the nigrostriatal dopaminergic system and distinct motor phenotypes
文献摘要：
The nigrostriatal dopaminergic(DA)system,which includes DA neurons in the ventral and dorsal tiers of the substantia nigra pars compacta(vSNc,dSNc)and DA terminals in the dorsal striatum,is critically implicated in motor control.Accumulating studies demonstrate that both the nigrostriatal DA system and motor function are impaired in aged subjects.However,it is unknown whether dSNc and vSNc DA neurons and striatal DA terminals age in similar patterns,and whether these changes parallel motor deficits.To address this,we performed ex vivo patch-clamp recordings in dSNc and vSNc DA neurons,measured striatal dopamine release,and analyzed motor behaviors in rodents.Spontaneous firing in dSNc and vSNc DA neurons and depolarization-evoked firing in dSNc DA neurons showed inverse V-shaped changes with age.But depolarization-evoked firing in vSNc DA neurons increased with age.In the dorsal striatum,dopamine release declined with age.In locomotor tests,12-month-old rodents showed hyperactive exploration,relative to 6-and 24-month-old rodents.Additionally,aged rodents showed significant deficits in coordination.Elevating dopamine levels with a dopamine transporter inhibitor improved both locomotion and coordination.Therefore,key components in the nigrostriatal DA system exhibit distinct aging patterns and may contribute to age-related alterations in locomotion and coordination.
文献关键词：
中图分类号：
作者姓名：
Jiang-peng Fan;Hui-zhen Geng;Ya-wei Ji;Tao Jia;Jennifer B.Treweek;An-an Li;Chun-yi Zhou;Viviana Gradinaru;Cheng Xiao
作者机构：
Jiangsu Province Key Laboratory in Brain diseases,Department of Biochemistry and Molecular Biology,School of Basic Medicine,Xuzhou Medical University,Xuzhou 221004,China;Jiangsu Province Key Laboratory in Anesthesiology,School of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China;NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs,School of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China;Division of Biology and Biological Engineering,California Institute of Technology,Pasadena,CA 91125,USA
文献出处：
引用格式：
[1]Jiang-peng Fan;Hui-zhen Geng;Ya-wei Ji;Tao Jia;Jennifer B.Treweek;An-an Li;Chun-yi Zhou;Viviana Gradinaru;Cheng Xiao-.Age-dependent alterations in key components of the nigrostriatal dopaminergic system and distinct motor phenotypes)[J].中国药理学报（英文版）,2022(04):862-875
A类：
nigrostriatal,tiers,vSNc,dSNc,Elevating
B类：
Age,dependent,alterations,key,components,dopaminergic,system,distinct,phenotypes,DA,which,includes,neurons,ventral,dorsal,substantia,nigra,pars,compacta,terminals,striatum,critically,implicated,control,Accumulating,studies,demonstrate,that,both,function,are,impaired,aged,subjects,However,unknown,whether,similar,patterns,these,changes,parallel,deficits,To,address,this,performed,vivo,patch,clamp,recordings,measured,release,analyzed,behaviors,rodents,Spontaneous,firing,depolarization,evoked,showed,inverse,shaped,But,increased,In,declined,locomotor,tests,month,old,hyperactive,exploration,relative,Additionally,significant,coordination,levels,transporter,inhibitor,improved,locomotion,Therefore,exhibit,aging,may,contribute,related
AB值：
0.429381
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
