典型文献
Mitochondrial Clk1-iron-DAT regulation pathway:a possible new therapeutic target for methamphetamine use disorder
文献摘要：
Methamphetamine(METH)is a potent psychostimulant and one of the most commonly used substances worldwide.METH produces strong rewarding and psychostimulant effects by increasing dopamine(DA)release in the brain reward system.Specifically,METH is first taken into the cytoplasm via the membrane DA transporter(DAT)and then binds to the vesicular monoamine transporter(called"VMAT2"),which blocks DA loading into vesicles and causes cytoplasm DA accumulation.This rapid increase in cytoplasm DA reverses the functional direction of the DAT and releases DA into the extracellular space[1].As such,DAT has been regarded as a major target in medication development for the treatment of psychostimulant use disorder[2].Developing new pharmacotherapies for METH addiction is urgent as there are currently none approved by the United States Food and Drug Administration or other authorities.The research highlighted herein presents an exciting new target for METH addiction medication development,Clk1(clock-1,also called Coq7),a mitochondrial hydroxylase involved in energy metabo-lism and DAT internalization[3].
文献关键词：
中图分类号：
作者姓名：
Briana Hempel;Zheng-Xiong Xi
作者机构：
Addiction Biology Unit,Molecular Targets and Medications Discovery Branch,National Institute on Drug Abuse,Intramural Research Program,Baltimore,MD 21224,USA
文献出处：
引用格式：
[1]Briana Hempel;Zheng-Xiong Xi-.Mitochondrial Clk1-iron-DAT regulation pathway:a possible new therapeutic target for methamphetamine use disorder)[J].中国药理学报（英文版）,2022(08):1887-1888
A类：
Clk1,psychostimulant,pharmacotherapies,Coq7
B类：
Mitochondrial,iron,DAT,regulation,pathway,possible,new,therapeutic,target,methamphetamine,disorder,Methamphetamine,METH,potent,most,commonly,used,substances,worldwide,produces,strong,rewarding,effects,by,increasing,dopamine,brain,system,Specifically,first,taken,into,cytoplasm,via,membrane,transporter,then,binds,vesicular,monoamine,called,VMAT2,which,blocks,loading,vesicles,causes,accumulation,This,rapid,increase,reverses,functional,direction,releases,extracellular,space,such,has,been,regarded,major,medication,development,treatment,Developing,addiction,urgent,there,are,currently,none,approved,United,States,Food,Drug,Administration,authorities,research,highlighted,herein,presents,exciting,clock,also,mitochondrial,hydroxylase,involved,energy,metabo,lism,internalization
AB值：
0.589919
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
