典型文献
Activation of mesocorticolimbic dopamine projections initiates cue-induced reinstatement of reward seeking in mice
文献摘要：
Drug addiction is characterized by relapse when addicts are re-exposed to drug-associated environmental cues,but the neural mechanisms underlying cue-induced relapse are unclear.In the present study we investigated the role of a specific dopaminergic(DA)pathway from ventral tegmental area(VTA)to nucleus accumbens core(NAcore)in mouse cue-induced relapse.Optical intracranial self-stimulation(oICSS)was established in DAT-Cre transgenic mice.We showed that optogenetic excitation of DA neurons in the VTA or their projection terminals in NAcore,NAshell or infralimbic prefrontal cortex(PFC-IL)was rewarding.Furthermore,activation of the VTA-NAcore pathway alone was sufficient and necessary to induce reinstatement of oICSS.In cocaine self-administration model,cocaine-associated cues activated VTA DA neurons as assessed by intracellular GCaMP signals.Cue-induced reinstatement of cocaine-seeking was triggered by optogenetic stimulation of the VTA-NAcore pathway,and inhibited by chemogenetic inhibition of this pathway.Together,these results demonstrate that cue-induced reinstatement of reward seeking is in part mediated by activation of the VTA-NAcore DA pathway.
文献关键词：
中图分类号：
作者姓名：
Man-yi Jing;Xiao-yan Ding;Xiao Han;Tai-yun Zhao;Min-min Luo;Ning Wu;Jin Li;Rui Song
作者机构：
State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Key Laboratory of Neuropsychopharmacology,Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China;Nanjing University of Chinese Medicine,Nanjing 210029,China;National Institute of Biological Sciences,Beijing 102206,China
文献出处：
引用格式：
[1]Man-yi Jing;Xiao-yan Ding;Xiao Han;Tai-yun Zhao;Min-min Luo;Ning Wu;Jin Li;Rui Song-.Activation of mesocorticolimbic dopamine projections initiates cue-induced reinstatement of reward seeking in mice)[J].中国药理学报（英文版）,2022(09):2276-2288
A类：
mesocorticolimbic,reinstatement,NAcore,oICSS,NAshell,infralimbic,GCaMP
B类：
Activation,projections,initiates,induced,seeking,mice,Drug,addiction,characterized,by,relapse,when,addicts,exposed,drug,associated,environmental,cues,but,neural,mechanisms,underlying,unclear,In,present,study,investigated,role,specific,dopaminergic,pathway,from,ventral,tegmental,area,VTA,nucleus,accumbens,mouse,Optical,intracranial,self,stimulation,was,established,DAT,Cre,transgenic,We,showed,that,optogenetic,excitation,neurons,their,terminals,prefrontal,cortex,PFC,rewarding,Furthermore,activation,alone,sufficient,necessary,cocaine,administration,model,activated,assessed,intracellular,signals,Cue,triggered,inhibited,chemogenetic,inhibition,this,Together,these,results,demonstrate,part,mediated
AB值：
0.46592
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