典型文献
Ion transporters:emerging agents for anticancer therapy
文献摘要：
Natural ion channels are pore-forming proteins that allow ions to pass through biomembranes,playing pivotal roles in almost all facets of cellular physiological functions.Biomimetic ion transporters were initially investigated for the purpose of treating life-threatening channelopathies.Recent studies have indicated that membrane-active synthetic ionophores possess desirable an-ticancer bioactivity against diverse cancer cell lines by disturbing intracellular ion homeostasis,triggering oxidative stress,and inducing apoptosis in tumors.Recent progress on ionophore-related antitumor therapeutics is comprehensively summarized in this review,including the molecular design principles,functional mechanisms,and characterization methods.Finally,we conclude this review by discussing the future opportunities and challenges in this field.It is anticipated that this review will provide an existing panoramic sketch and future directions toward the construction of novel ion transporters with simplified preparation procedures,enhanced biocompatibility,and desirable anti-proliferative activities,which may further accelerate their therapeutic applications in clinical treatments.
文献关键词：
中图分类号：
作者姓名：
Tengfei Yan;Xin Zheng;Shengda Liu;Yingping Zou;Junqiu Liu
作者机构：
State Key Laboratory of Powder Metallurgy,College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China;College of Material,Chemistry and Chemical Engineering,Key Laboratory of Organosilicon Chemistry and Material Technology,Ministry of Education,Key Laboratory of Organosilicon Material Technology of Zhejiang Province,Hangzhou Normal University,Hangzhou 311121,China
文献出处：
引用格式：
[1]Tengfei Yan;Xin Zheng;Shengda Liu;Yingping Zou;Junqiu Liu-.Ion transporters:emerging agents for anticancer therapy)[J].中国科学:化学（英文版）,2022(07):1265-1278
A类：
biomembranes,channelopathies,ionophores,ticancer,ionophore
B类：
Ion,transporters,emerging,agents,anticancer,therapy,Natural,channels,are,pore,forming,proteins,that,allow,pass,through,playing,pivotal,roles,almost,facets,physiological,functions,Biomimetic,were,initially,investigated,purpose,treating,threatening,Recent,studies,have,indicated,active,synthetic,possess,desirable,bioactivity,against,diverse,lines,by,disturbing,intracellular,homeostasis,triggering,oxidative,stress,inducing,apoptosis,tumors,progress,related,antitumor,therapeutics,comprehensively,summarized,this,review,including,molecular,design,principles,functional,mechanisms,characterization,methods,Finally,conclude,discussing,future,opportunities,challenges,field,It,anticipated,will,provide,existing,panoramic,sketch,directions,toward,construction,novel,simplified,preparation,procedures,enhanced,biocompatibility,proliferative,activities,which,may,further,accelerate,their,applications,clinical,treatments
AB值：
0.683987
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