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典型文献
Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs
文献摘要:
Differentiated somatic cells can be reprogrammed into induced pluripotent stem cells(iPSCs)by overexpression of specific tran-scription factors,such as Yamanaka factors(Oct4,Sox2,Klf4,and c-Myc,abbreviated as OSKM).iPSCs hold great promise for broad clinical application due to their extraordinary ability to self-renew and differentiate into different functional cell types.
文献关键词:
作者姓名:
Kun Zhao;Xiaoxiang Sun;Caihong Zheng;Mengting Wang;Zhu Xu;Mingzhu Wang;Jiayu Chen;Mingyue Guo;Rongrong Le;Li Wu;Yibin Wang;Xiaochen Kou;Yanhong Zhao;Jiqing Yin;Hong Wang;Zhiyong Mao;Shaorong Gao;Shuai Gao
作者机构:
Translational Medical Center for Stem Cell Therapy&Institute for Regenerative Medicine,Shanghai East Hospital,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200120,China;Clinical and Translational Research Center of Shanghai First Maternity&Infant Hospital,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China;Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences,and China National Center for Bioinformation,Beijing 100101,China;Key Laboratory of Animal Genetics,Breeding and Reproduction of the MARA,National Engineering Laboratory for Animal Breeding,College of Animal Science and Technology,China Agricultural University,Beijing 100193,China
引用格式:
[1]Kun Zhao;Xiaoxiang Sun;Caihong Zheng;Mengting Wang;Zhu Xu;Mingzhu Wang;Jiayu Chen;Mingyue Guo;Rongrong Le;Li Wu;Yibin Wang;Xiaochen Kou;Yanhong Zhao;Jiqing Yin;Hong Wang;Zhiyong Mao;Shaorong Gao;Shuai Gao-.Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs)[J].科学通报(英文版),2022(11):1126-1130
A类:
Xrcc1,Yamanaka,OSKM
B类:
Enhancement,mediated,base,excision,repair,improves,genetic,stability,pluripotency,iPSCs,Differentiated,somatic,cells,can,be,reprogrammed,into,induced,pluripotent,stem,by,overexpression,specific,tran,scription,factors,such,Oct4,Sox2,Klf4,Myc,abbreviated,hold,great,promise,broad,clinical,application,due,their,extraordinary,self,renew,differentiate,functional,types
AB值:
0.724061
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