典型文献
Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity
文献摘要：
Cell plasticity endows differentiated cells with competence to be reprogrammed to other lineages.Although extrinsic factors driving cell-identity conversion have been extensively characterized,it remains elusive which intrinsic epigenetic attributes,including high-order chromatin organization,delineate cell plasticity.By analysing the transcription-factor-induced transdifferentiation from fibroblasts to hepatocytes,we uncovered contiguous compartment-switchable regions(CSRs)as a unique chromatin unit.Specifically,compartment B-to-A CSRs,enriched with hepatic genes,possessed a mosaic status of inactive chromatin and pre-existing and continuous accessibility in fibroblasts.Pre-existing accessibility enhanced the binding of inducible factor Foxa3,which triggered epigenetic activation and chromatin interaction as well as hepatic gene expression.Notably,these changes were restrained within B-to-A CSR boundaries that were defined by CTCF occupancy.Moreover,such chromatin organization and mosaic status were detectable in different cell types and involved in multiple reprogramming processes,suggesting an intrinsic chromatin attribute in understanding cell plasticity.
文献关键词：
中图分类号：
作者姓名：
Xiaolong Ma;Xuan Cao;Linying Zhu;Ying Li;Xuelong Wang;Baihua Wu;Gang Wei;Lijian Hui
作者机构：
State Key Laboratory of Cell Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences;University of Chinese Academy of Sciences,Shanghai 200031,China;CAS Key Laboratory of Computational Biology,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China;Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China;Bio-Research Innovation Center,Shanghai Institute of Biochemistry and Cell Biology,Suzhou 215121,China;Schoolof Life Science and Technology,ShanghaiTech University,Shanghai 201210,China
文献出处：
引用格式：
[1]Xiaolong Ma;Xuan Cao;Linying Zhu;Ying Li;Xuelong Wang;Baihua Wu;Gang Wei;Lijian Hui-.Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity)[J].国家科学评论（英文版）,2022(06):95-108
A类：
CSRs,Foxa3
B类：
Pre,existing,chromatin,accessibility,switchable,repressive,compartment,delineates,plasticity,Cell,endows,differentiated,cells,competence,reprogrammed,other,lineages,Although,extrinsic,factors,driving,identity,conversion,have,been,extensively,characterized,remains,elusive,which,intrinsic,epigenetic,attributes,including,high,order,organization,By,analysing,transcription,induced,transdifferentiation,from,fibroblasts,hepatocytes,uncovered,contiguous,regions,unique,unit,Specifically,enriched,hepatic,genes,possessed,mosaic,status,inactive,continuous,enhanced,binding,inducible,triggered,activation,interaction,well,expression,Notably,these,changes,were,restrained,within,boundaries,that,defined,by,CTCF,occupancy,Moreover,such,detectable,types,involved,multiple,reprogramming,processes,suggesting,understanding
AB值：
0.602997
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