典型文献
Dendritic cells maturation facilitated by group-adjustable lipopolysaccharide analogues synthesized via RAFT polymerization
文献摘要：
Transforming immature DCs into mature state to activate cellular immunity is a critical step in initiating immunoprophylaxis and immunotherapy.Lipopolysaccharides(LPS)can promote DCs maturation by bind-ing receptor on DCs surface,but their clinical application is limited due to biological toxicity.Although many LPS analogues have been developed,complex synthesis and purification hinder their practical appli-cation.Here,we propose a novel and simple strategy to synthesize LPS analogues with adjustable struc-tural units.Using monomer units similar to the key functional groups of LPS,we synthesize LPS analogues with different group ratios by RAFT polymerization.The obtained analogues have little negative effect on cell viability.Compared with LPS,the analogues show greater promoting effect on DCs maturation.And the analogues can be applied to different scenarios since the degrees of promoting DCs maturation by LPS analogues with different group ratios are different.This strategy provides a new direction for syn-thesizing LPS analogues,and it has the potential to produce LPS analogues on a large scale with tunable promoting DCs maturation effect.
文献关键词：
中图分类号：
作者姓名：
Xingyu Heng;Ruyan Feng;Lijuan Zhu;Liyin Yu;Gaojian Chen;Hong Chen
作者机构：
College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,China;Center for Soft Condensed Matter Physics and Interdisciplinary Research,Soochow University,Suzhou 215006,China
文献出处：
引用格式：
[1]Xingyu Heng;Ruyan Feng;Lijuan Zhu;Liyin Yu;Gaojian Chen;Hong Chen-.Dendritic cells maturation facilitated by group-adjustable lipopolysaccharide analogues synthesized via RAFT polymerization)[J].中国化学快报（英文版）,2022(09):4331-4334
A类：
immunoprophylaxis
B类：
Dendritic,cells,maturation,facilitated,by,adjustable,lipopolysaccharide,analogues,synthesized,RAFT,polymerization,Transforming,immature,DCs,into,state,activate,cellular,immunity,critical,step,initiating,immunotherapy,Lipopolysaccharides,LPS,can,promote,bind,receptor,surface,but,their,clinical,application,limited,due,biological,toxicity,Although,many,have,been,developed,complex,synthesis,purification,hinder,practical,Here,we,propose,novel,simple,strategy,struc,tural,units,Using,monomer,similar,key,functional,groups,different,ratios,obtained,little,negative,effect,viability,Compared,show,greater,promoting,And,applied,scenarios,since,degrees,This,provides,new,direction,thesizing,has,potential,produce,large,scale,tunable
AB值：
0.52863
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