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典型文献
Probing and modulating the interactions of the DNAzyme with DNA-functionalized nanoparticles
文献摘要:
DNA-functionalized gold nanoparticles are one of the most versatile bionanomaterials for biomedical and clinical diagnosis.Herein,we discovered that the performance of DNAzyme cleaving the substrate is highly related to its length.This intriguing phenomenon only appears at the interfaces of DNA-functionalized gold nanoparticles.We systematically investigated the causes of this phenomenon.We conjectured that the DNAzyme with extended nucleotides that do not match its substrate strand is vul-nerable to non-specific adsorption,electrostatic repulsion,and steric hindrance.Based on our improved understanding of this phenomenon,we have successfully developed a highly sensitive and specific am-plifiable biosensor to detect human apurinic/apyrimidinic endonuclease 1.
文献关键词:
作者姓名:
Yuqiang Hu;Zhen Zhang;Wei Zhang;Minghao Hu;Xianjin Xiao;Tongbo Wu
作者机构:
School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Institute of Reproductive Health/Center of Reproductive Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Obstetrics and Gynaecology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
引用格式:
[1]Yuqiang Hu;Zhen Zhang;Wei Zhang;Minghao Hu;Xianjin Xiao;Tongbo Wu-.Probing and modulating the interactions of the DNAzyme with DNA-functionalized nanoparticles)[J].中国化学快报(英文版),2022(06):3026-3030
A类:
bionanomaterials,nerable,plifiable,apurinic,apyrimidinic
B类:
Probing,modulating,interactions,DNAzyme,functionalized,nanoparticles,gold,are,one,most,versatile,biomedical,clinical,diagnosis,Herein,we,discovered,that,performance,cleaving,substrate,highly,related,its,length,This,intriguing,phenomenon,only,appears,interfaces,We,systematically,investigated,causes,this,conjectured,extended,nucleotides,not,match,strand,vul,specific,adsorption,electrostatic,repulsion,steric,hindrance,Based,our,improved,understanding,have,successfully,developed,sensitive,am,biosensor,detect,human,endonuclease
AB值:
0.597109
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