Most studies of coronavirus disease 2019(COVID-19)progression have focused on the transfer of patients within secondary or tertiary care hospitals from regular wards to intensive care units.Little is known about the risk factors predicting the progression to severe COVID-19 among patients in community iso-lation,who are either asymptomatic or suffer from only mild to moderate symptoms.Using a multivari-able competing risk survival analysis,we identify several important predictors of progression to severe COVID-19-rather than to recovery-among patients in the largest community isolation center in Wuhan,China from 6 February 2020(when the center opened)to 9 March 2020(when it closed).All patients in community isolation in Wuhan were either asymptomatic or suffered from mild to moderate COVID-19 symptoms.We performed competing risk survival analysis on time-to-event data from a cohort study of all COVID-19 patients(n=1753)in the isolation center.The potential predictors we inves-tigated were the routine patient data collected upon admission to the isolation center:age,sex,respira-tory symptoms,gastrointestinal symptoms,general symptoms,and computed tomography(CT)scan signs.The main outcomes were time to severe COVID-19 or recovery.The factors predicting progression to severe COVID-19 were:male sex(hazard ratio(HR)=1.29,95％confidence interval(CI)1.04-1.58,p=0.018),young and old age,dyspnea(HR=1.58,95％CI 1.24-2.01,p＜0.001),and CT signs of ground-glass opacity(HR=1.39,95％CI 1.04-1.86,p=0.024)and infiltrating shadows(HR=1.84,95％CI 1.22-2.78,p=0.004).The risk of progression was found to be lower among patients with nausea or vomiting(HR=0.53,95％CI 0.30-0.96,p=0.036)and headaches(HR=0.54,95％CI 0.29-0.99,p=0.046).Our results suggest that several factors that can be easily measured even in resource-poor set-tings(dyspnea,sex,and age)can be used to identify mild COVID-19 patients who are at increased risk of disease progression.Looking for CT signs of ground-glass opacity and infiltrating shadows may be an affordable option to support triage decisions in resource-rich settings.Common and unspecific symptoms(headaches,nausea,and vomiting)are likely to have led to the identification and subsequent community isolation of COVID-19 patients who were relatively unlikely to deteriorate.Future public health and clinical guidelines should build on this evidence to improve the screening,triage,and monitoring of COVID-19 patients who are asymtomatic or suffer from mild to moderate symptoms.

Simiao Chen;Hui Sun;Mei Heng;Xunliang Tong;Pascal Geldsetzer;Zhuoran Wang;Peixin Wu;Juntao Yang;Yu Hu;Chen Wang;Till B?rnighausen

Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China;Heidelberg Institute of Global Health(HIGH),Faculty of Medicine and University Hospital,Heidelberg University,Heidelberg 69120,Germany;Institute of Hematology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Pulmonary and Critical Care Medicine,Beijing Hospital,Beijing 100730,China;National Center of Gerontology,Institute of Geriatric Medicine,Beijing 100730,China;Division of Primary Care and Population Health,Department of Medicine,Stanford University,Stanford,CA 94305,USA;Peking Union Medical College Hospital,Beijing 100730,China;State Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China;National Clinical Research Center for Respiratory Diseases,Beijing 100029,China;Department of Pulmonary and Critical Care Medicine,Center of Respiratory Medicine,China-Japan Friendship Hospital,Beijing 100029,China

工程（英文）

[1]Simiao Chen;Hui Sun;Mei Heng;Xunliang Tong;Pascal Geldsetzer;Zhuoran Wang;Peixin Wu;Juntao Yang;Yu Hu;Chen Wang;Till B?rnighausen-.Factors Predicting Progression to Severe COVID-19:A Competing Risk Survival Analysis of 1753 Patients in Community Isolation in Wuhan,China)[J].工程（英文）,2022(06):99-106

multivari,asymtomatic

Factors,Predicting,Progression,Severe,Competing,Risk,Survival,Analysis,Patients,Community,Isolation,Wuhan,China,Most,studies,coronavirus,disease,progression,have,focused,transfer,patients,within,secondary,tertiary,care,hospitals,from,regular,wards,intensive,units,Little,known,about,risk,factors,predicting,severe,among,community,who,either,asymptomatic,only,mild,moderate,symptoms,Using,competing,survival,analysis,identify,several,important,predictors,rather,than,recovery,largest,isolation,center,February,when,opened,March,closed,All,were,suffered,We,performed,event,data,cohort,study,all,potential,inves,tigated,routine,collected,upon,admission,sex,respira,tory,gastrointestinal,general,computed,tomography,scan,signs,main,outcomes,male,hazard,ratio,confidence,interval,young,old,dyspnea,ground,glass,opacity,infiltrating,shadows,was,found,be,lower,nausea,vomiting,headaches,Our,results,suggest,that,easily,measured,resource,poor,increased,Looking,may,affordable,option,support,triage,decisions,rich,settings,Common,unspecific,led,identification,subsequent,relatively,unlikely,deteriorate,Future,public,health,clinical,guidelines,should,build,this,evidence,improve,screening,monitoring

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