典型文献
Incidence,Survival Outcome,and Prognostic Nomogram of Patients with Angioimmunoblastic T-cell Lymphoma:a Population-based Analysis
文献摘要：
Objective:Due to the rarity of angioimmunoblastic T-cell lymphoma(AITL),very limited data concerning its incidence patterns and prognostic factors are available.This study aimed to explore the incidence,characteristics,survival outcomes,and prognostic factors of AITL.Methods:Age-adjusted incidence and temporal trends were calculated based on 1247 AITL patients from the National Cancer Institute's Surveillance,Epidemiology,and End Results(SEER)-13 database.A total of 1525 AITL patients from the SEER-18 database and 43 patients from our single center were included for survival analysis and nomogram construction.Results:The age-adjusted incidence for overall cohort was 0.123[95％confidence interval(CI),0.117-0.131)per 100 000 during 1992-2017.The overall incidence increased steeply at the rate of 15.3％(95％CI 11.0％-19.8％,P＜0.001)per year during 1992-2004,but remained stable during 2004-2017(P=0.200).Similar incidence trends were observed in age,sex,and stage subgroups.The final nomograms consisted of four variables:age at diagnosis,sex,Ann Arbor stage,and primary site.The concordance index(C-index)of the nomogram for 5-year overall survival prediction was 0.717,0.690 and 0.820 in the training cohort,validation cohort-1 and cohort-2,respectively.Regarding the disease-specific survival(DSS),the nomogram also demonstrated a good discrimination level,with the C-index for predicting the probability of DSS at 5 years of 0.716,0.682 and 0.813 for the three cohorts,respectively.The calibration displayed good concordance between the nomogram-predicted and actual observed outcomes.Conclusion:The age-adjusted incidence for AITL was low during 1992-2017.The incidence continuously increased during 1992-2004,but remained stable during 2004-2017.The nomograms as proposed may provide a favorable and accurate prognostic survival prediction in AITL.
文献关键词：
中图分类号：
作者姓名：
Hai-zhu CHEN;Yun-xia TAO;Yu ZHOU;Qiao-feng ZHONG;Li-qiang ZHOU;Yuan-kai SHI
作者机构：
Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs,Beijing 100021,China
文献出处：
引用格式：
[1]Hai-zhu CHEN;Yun-xia TAO;Yu ZHOU;Qiao-feng ZHONG;Li-qiang ZHOU;Yuan-kai SHI-.Incidence,Survival Outcome,and Prognostic Nomogram of Patients with Angioimmunoblastic T-cell Lymphoma:a Population-based Analysis)[J].当代医学科学(英文),2022(06):1220-1230
A类：
Angioimmunoblastic,angioimmunoblastic
B类：
Incidence,Survival,Outcome,Prognostic,Nomogram,Patients,cell,Lymphoma,Population,Analysis,Objective,Due,rarity,lymphoma,AITL,very,limited,concerning,its,incidence,patterns,prognostic,factors,are,available,This,study,aimed,explore,characteristics,survival,outcomes,Methods,Age,adjusted,temporal,trends,were,calculated,patients,from,National,Cancer,Institute,Surveillance,Epidemiology,End,Results,SEER,database,total,single,center,included,analysis,construction,overall,was,confidence,interval,per,during,increased,steeply,but,remained,stable,Similar,observed,sex,stage,subgroups,final,nomograms,consisted,four,variables,diagnosis,Ann,Arbor,primary,site,concordance,prediction,training,validation,respectively,Regarding,disease,specific,DSS,also,demonstrated,good,discrimination,level,predicting,probability,years,three,cohorts,calibration,displayed,between,predicted,actual,Conclusion,low,continuously,proposed,may,provide,favorable,accurate
AB值：
0.508521
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