典型文献
Value of Preoperative Hematological Parameters in the Prognosis of Gastric Cancer Patients Undergoing a Total Gastrectomy
文献摘要：
Objective:This study aimed to evaluate the relationships between the albumin/globulin ratio(AGR),neutrophil/lymphocyte ratio(NLR),and platelet/lymphocyte ratio(PLR)and clinicopathological information for gastric cancer patients.In addition,the prognostic values of these hematological parameters for resectable gastric cancer patients undergoing a total gastrectomy were determined.Methods:A total of 245 patients with gastric cancer who underwent a total gastrectomy at our hospital between January 1,2005,and December 30,2015,were enrolled into this study.The preoperative AGR,NLR,and PLR in the serum samples of the patients were measured.The relationships between the hematological parameters and the disease-free survival(DFS)as well as overall survival(OS)were analyzed by statistical analysis.Results:The cutoff values of AGR,NLR,and PLR were 1.57,3.5,and 193,respectively.Univariate analyses demonstrated that a low AGR,a high NLR,and a high PLR were significant risk factors for a poor prognosis.According to multivariate analysis,a high PLR was found to be independently associated with a poor survival.Additionally,when age was considered as a stratified factor,univariate analyses demonstrated that a low AGR had the tendency to be correlated with a shorter DFS in nonelderly patients(＜65 years old).A low AGR was significantly correlated with a shorter DFS and OS in elderly patients(≥65 years old).Conclusion:AGR,NLR,and PLR are independent risk factors associated with a poor gastric cancer survival by univariate analysis,and AGR is an independent risk factor for predicting DFS and OS in elderly patients(＞65 years old)with gastric cancer after total gastrectomy.
文献关键词：
中图分类号：
作者姓名：
Xi-shan ZHU;Ye ZHAO;Fei-yan MA;Shi-kai WU
作者机构：
Oncology Department,Peking University First Hospital,Beijing 100034,China;Pathology Department,Peking University First Hospital,Beijing 100034,China
文献出处：
引用格式：
[1]Xi-shan ZHU;Ye ZHAO;Fei-yan MA;Shi-kai WU-.Value of Preoperative Hematological Parameters in the Prognosis of Gastric Cancer Patients Undergoing a Total Gastrectomy)[J].当代医学科学(英文),2022(02):348-356
A类：
nonelderly
B类：
Value,Preoperative,Hematological,Parameters,Prognosis,Gastric,Cancer,Patients,Undergoing,Total,Gastrectomy,Objective,This,study,aimed,evaluate,relationships,between,albumin,globulin,ratio,AGR,neutrophil,lymphocyte,NLR,platelet,PLR,clinicopathological,information,gastric,cancer,patients,In,addition,prognostic,values,these,hematological,parameters,resectable,undergoing,total,gastrectomy,were,determined,Methods,who,underwent,our,hospital,January,December,enrolled,into,this,preoperative,serum,samples,measured,disease,free,survival,DFS,well,overall,OS,analyzed,by,statistical,analysis,Results,cutoff,respectively,Univariate,analyses,demonstrated,that,low,high,risk,factors,poor,prognosis,According,multivariate,was,found,independently,associated,Additionally,when,age,considered,stratified,univariate,had,tendency,correlated,shorter,years,old,significantly,Conclusion,are,predicting,after
AB值：
0.486129
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