典型文献
Hypertension Exacerbates Severity and Outcomes of CO VID-19 in Elderly Patients:A Retrospective Observational Study
文献摘要：
To evaluate the impact of hypertension on the clinical outcome of COVID-19 patients aged 60 years old and older.Methods:This single-center retrospective cohort study enrolled consecutive COVID-19 patients aged 60 years old and older,who were admitted to Liyuan Hospital from January 1,2020 to April 25,2020.All included patients were divided into two groups:hypertension and nonhypertension group.The baseline demographic characteristics,laboratory test results,chest computed tomography(CT)images and clinical outcomes were collected and analyzed.The prognostic value of hypertension was determined using binary logistic regression.Results:Among the 232 patients included in the analysis,105(45.3％)patients had comorbid hypertension.Compared to the nonhypertension group,patients in the hypertension group had higher neutrophil-to-lymphocyte ratios,red cell distribution widths,lactate dehydrogenase,high-sensitivity C-reactive protein,D-dimer and severity of lung lesion,and lower lymphocyte counts(all P＜0.05).Furthermore,the hypertension group had a higher proportion of intensive care unit admissions[24(22.9％)vs.14(11.0％),P=0.02)and deaths[16(15.2％)vs.3(2.4％),P＜0.001]and a significantly lower probability of survival(P＜0.001)than the nonhypertension group.Hypertension(OR:4.540,95％CI:1.203-17.129,P=0.026)was independently correlated with all-cause in-hospital death in elderly patients with COVID-19.Conclusion:The elderly COVID-19 patients with hypertension tend to have worse conditions at baseline than those without hypertension.Hypertension may be an independent prognostic factor of poor clinical outcome in elderly COVID-19 patients.
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中图分类号：
作者姓名：
Li-song DAI;Meng-pei ZHU;Yu-min LI;Hong-mei ZHOU;Hong-li LIAO;Pan-pan CHENG;Xin-yue XIA;Xue-yun YAO;Hui-juan ZHANG;Xiao-qi LIU;Wei HUANG;Lei WAN;Xiang-yang XU;Fu-rong WANG;Cheng-qi XU
作者机构：
Department of Radiology,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430070,China;Department of Respiratory,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430070,China;Department of Radiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430015,China;Department of Radiology,Wuhan Eighth Hospital,Wuhan 430014,China;Department of Cardiology,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430070,China;Department of Ultrasound,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430070,China;Key Laboratory of Molecular Biophysics of the Ministry of Education,Cardio-X Institute,College of Life Science and Technology and Center for Human Genome Research,Huazhong University of Science and Technology,Wuhan 430070,China
文献出处：
引用格式：
[1]Li-song DAI;Meng-pei ZHU;Yu-min LI;Hong-mei ZHOU;Hong-li LIAO;Pan-pan CHENG;Xin-yue XIA;Xue-yun YAO;Hui-juan ZHANG;Xiao-qi LIU;Wei HUANG;Lei WAN;Xiang-yang XU;Fu-rong WANG;Cheng-qi XU-.Hypertension Exacerbates Severity and Outcomes of CO VID-19 in Elderly Patients:A Retrospective Observational Study)[J].当代医学科学(英文),2022(03):561-568
A类：
Exacerbates,Liyuan,nonhypertension
B类：
Hypertension,Severity,Outcomes,Elderly,Patients,Retrospective,Observational,Study,To,evaluate,impact,clinical,patients,aged,years,older,Methods,This,single,center,retrospective,cohort,study,enrolled,consecutive,who,were,admitted,Hospital,from,January,April,All,included,divided,into,two,groups,baseline,demographic,characteristics,laboratory,test,results,chest,computed,tomography,images,outcomes,collected,analyzed,prognostic,value,was,determined,using,binary,logistic,regression,Results,Among,analysis,had,comorbid,Compared,higher,neutrophil,lymphocyte,ratios,cell,distribution,widths,lactate,dehydrogenase,sensitivity,reactive,protein,dimer,severity,lung,lesion,lower,counts,all,Furthermore,proportion,intensive,care,unit,admissions,deaths,significantly,probability,survival,than,independently,correlated,cause,hospital,elderly,Conclusion,tend,have,worse,conditions,those,without,may,be,poor
AB值：
0.552361
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