典型文献
Phenomapping approach to interpreting coronary dimensions in febrile children
文献摘要：
Importance::Coronary artery dilation may occur in febrile children with and without Kawasaki disease (KD).Objective::We explored the application of unsupervised learning algorithms in the detection of novel patterns of coronary artery phenotypes in febrile children with and without KD.Methods::A total of 239 febrile children (59 non-KD and 180 KD patients), were recruited. Unsupervised hierarchical clustering analysis of phenotypic data including age, hemoglobin, white cell count, platelet count, C-reactive protein, erythrocyte sedimentation rate, albumin, alanine aminotransferase, aspartate aminotransferase, and coronary artery
z scores were performed.
Results::Using a cutoff
z score of 2.5, the specificity was 98.3% and the sensitivity was 22.1% for differentiating non-KD from KD patients. Clustering analysis identified three phenogroups that differed in a clinical, laboratory, and echocardiographic parameters. Compared with phenogroup I, phenogroup III had the highest prevalence of KD (91%), worse inflammatory markers, more deranged liver function, higher coronary artery
z scores, and lower hematocrit and albumin levels. Abnormal blood parameters in febrile children with
z scores of coronary artery segments <0.5 and 0.5-1.5 was associated with increased risks of having KD to 8.7 (
P = 0.003) and 4.4 (
P = 0.002), respectively.
Interpretation::Phenomapping of febrile children with and without KD identified useful laboratory parameters that aid the diagnosis of KD in febrile children with relatively normal-sized coronary arteries.
文献关键词：
Coronary artery;Febrile children;Kawasaki disease;Phenomapping
中图分类号：
作者姓名：
Tang Haoxun;Guo Xin;Nie Xiaolu;Zheng Lin;Liu Gang;Wong Wilfred Hing-Sang;Cheung Yiu-Fai
作者机构：
Heart Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;Department of Infectious Disease, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;Department of Echocardiography, Beijing Children' s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China;Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China
文献出处：
引用格式：
[1]Tang Haoxun;Guo Xin;Nie Xiaolu;Zheng Lin;Liu Gang;Wong Wilfred Hing-Sang;Cheung Yiu-Fai-.Phenomapping approach to interpreting coronary dimensions in febrile children)[J].儿科学研究（英文）,2022(04):233-240
A类：
Phenomapping,phenogroups,phenogroup,deranged
B类：
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AB值：
0.533615
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