典型文献
Relationship Between Myocardial Injury and Expression of PGC-1α and Its Coactivators in Chronic Keshan Disease
文献摘要：
Objective:Keshan disease(KD)is a mitochondrial cardiomyopathy.The present study explored the roles of peroxisome proliferator-activated receptor(PPAR)-γ coactivator-1α(PGC-1α),the key regulator of mitochondrial structure and function,and its coactivators in myocardial injury in chronic KD.Furthermore,the usefulness of these molecules in the diagnosis of chronic KD was assessed.Methods:In the present case-control study,43 patients with chronic KD and 30 healthy individuals living in KD endemic areas were included.The myocardial injury indicators and mRNA expression levels of PGC-1α,nuclear respiratory factor 1(NRF1),PPARα,and estrogen-related receptor alpha(ERRα)in peripheral blood were examined.Results:It was found that the levels of atrial natriuretic peptide,creatine kinase,and lactate dehydrogenase(LDH)were higher in patients with chronic KD,when compared to controls,while the level of bradykinin was lower.Furthermore,the PGC-1α,NRF1 and PPARα mRNA levels were higher in patients with KD.The area under the receiver operating characteristic curve and the optimal diagnostic threshold of LDH was 0.937 and 304.0 U/L,respectively.It is noteworthy that the area under the combined receiver operating characteristic curve was larger,when compared to that for LDH detection alone(Z=2.055,P=0.0399).The area under the curve for the"LDH+PPARα"combination was 0.984,with 96.7％sensitivity and 93.0％specificity.Conclusion:The combined detection of LDH and the expression of PPARα can be performed to diagnose the chronic KD.
文献关键词：
中图分类号：
作者姓名：
Shuai JIANG;Qian-ru YE;Rong-xia ZHEN;Juan-niu ZHANG;Yi-yi ZHANG;Xu LIU;Jie HOU
作者机构：
Institute of Keshan Disease,Chinese Center for Endemic Disease Control,Harbin Medical University,Harbin 150081,China;Affiliated Hospital of Jilin Medical College,Jilin 132013,China;Hangzhou Center for Disease Control and Prevention,Hangzhou 310021,China;Sanya Institute of Technology,Sanya 572022,China;Inner Mongolia Autonomous Region Mental Health Center,Hohhot,010010,China
文献出处：
引用格式：
[1]Shuai JIANG;Qian-ru YE;Rong-xia ZHEN;Juan-niu ZHANG;Yi-yi ZHANG;Xu LIU;Jie HOU-.Relationship Between Myocardial Injury and Expression of PGC-1α and Its Coactivators in Chronic Keshan Disease)[J].当代医学科学(英文),2022(01):85-92
A类：
Coactivators,Keshan,coactivators,LDH+PPAR
B类：
Relationship,Between,Myocardial,Injury,Expression,PGC,Its,Chronic,Disease,Objective,disease,KD,mitochondrial,cardiomyopathy,present,study,explored,roles,peroxisome,proliferator,activated,receptor,key,regulator,structure,function,its,myocardial,injury,chronic,Furthermore,usefulness,these,molecules,diagnosis,was,assessed,Methods,case,patients,healthy,individuals,living,endemic,areas,were,included,indicators,expression,levels,nuclear,respiratory,NRF1,estrogen,related,alpha,ERR,peripheral,blood,examined,Results,found,that,atrial,natriuretic,peptide,creatine,kinase,lactate,dehydrogenase,higher,when,compared,controls,while,bradykinin,lower,under,receiver,operating,characteristic,curve,optimal,diagnostic,threshold,respectively,noteworthy,combined,larger,detection,alone,combination,sensitivity,specificity,Conclusion,can,be,performed,diagnose
AB值：
0.501974
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