典型文献
Inflammasomes in Human Immunodeficiency Virus Type 1 Infection
文献摘要：
Innate immune responses are the host's first line of defense against human immunodeficiency virus type 1 (HIV-1) infection, with pattern recognition receptors detecting viral specific pathogen-associated molecular patterns and initiating antiviral responses. In response to HIV-1 nucleic acids or proteins, some pattern recognition receptors have the ability to assemble a large multiprotein complex called the inflammasome, which triggers pro-inflammatory cytokine release and a form of lytic programmed cell death called pyroptosis. Here, we review our current understanding of the mechanism of the inflammasome in sensing HIV-1 infection. Furthermore, we discuss the contribution of inflammasome activation in HIV-1 pathogenesis as well as potential strategies of targeting inflammasome activation for the treatment of HIV-1 infection.
文献关键词：
HIV-1;Inflammasomes;CARD8 protein;Pyroptosis
中图分类号：
作者姓名：
Wang Qiankun;Shan Liang
作者机构：
Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
文献出处：
引用格式：
[1]Wang Qiankun;Shan Liang-.Inflammasomes in Human Immunodeficiency Virus Type 1 Infection)[J].感染性疾病和免疫（英文）,2022(04):248-252
A类：
Inflammasomes,CARD8
B类：
Human,Immunodeficiency,Virus,Type,Infection,Innate,immune,responses,are,host,first,line,defense,against,human,immunodeficiency,virus,type,HIV,infection,recognition,receptors,detecting,specific,associated,molecular,patterns,initiating,antiviral,nucleic,acids,proteins,have,ability,assemble,large,multiprotein,complex,called,inflammasome,which,triggers,inflammatory,cytokine,release,form,lytic,programmed,cell,death,pyroptosis,Here,review,our,current,understanding,mechanism,sensing,Furthermore,discuss,contribution,activation,pathogenesis,well,potential,strategies,targeting,treatment,Pyroptosis
AB值：
0.62453
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