典型文献
Potential Mechanisms and Effects of Chinese Medicines in Treatment of Diabetic Atherosclerosis by Modulating NLRP3 Inflammasome:A Narrative Review
文献摘要：
Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3)is an intracellular sensor that detects endogenous danger signals and environmental irritants to assemble into the NLRP3 inflammasome.Activation of the NLRP3 inflammasome leads to the secretion of the proinflammatory cytokines interleutkin(IL)-1 β and IL-18 and induces pyroptosis.Recent studies have shown that the NLRP3 inflammasome participates in the initiation and progression of diabetic atherosclerosis through pathological mechanisms such as β-cell dysfunction,insulin resistance,endothelial cell dysfunction,monocyte adhesion and infiltration,and smooth muscle cell proliferation and migration.In diabetic atherosclerosis,Chinese medicine has been proven effective for the inflammatory response mediated by the NLRP3 inflammasome.This review summarizes the latest progress on the NLRP3 inflammasome in the pathogenesis and potential Chinese medicine treatment of diabetic atherosclerosis.
文献关键词：
中图分类号：
作者姓名：
YUAN Jia-yao;FU Yu;FENG Zhi-hai;SANG Feng;SHAO Ming-yi;LI Lei-lei
作者机构：
School of First Clinical,Henan University of Chinese Medicine,Zhengzhou(450000),China;Department of Endocrinology,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou(450000),China;Department of Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine of Henan Province,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou(450000),China;Department of Gastroenterology,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou(450000),China
文献出处：
引用格式：
[1]YUAN Jia-yao;FU Yu;FENG Zhi-hai;SANG Feng;SHAO Ming-yi;LI Lei-lei-.Potential Mechanisms and Effects of Chinese Medicines in Treatment of Diabetic Atherosclerosis by Modulating NLRP3 Inflammasome:A Narrative Review)[J].中国结合医学杂志（英文版）,2022(08):753-761
A类：
Inflammasome,irritants,interleutkin
B类：
Potential,Mechanisms,Effects,Chinese,Medicines,Treatment,Diabetic,Atherosclerosis,by,Modulating,NLRP3,Narrative,Review,Nucleotide,binding,oligomerization,domain,like,receptor,family,pyrin,containing,intracellular,sensor,that,detects,endogenous,danger,signals,environmental,assemble,into,inflammasome,Activation,leads,secretion,proinflammatory,cytokines,induces,pyroptosis,Recent,studies,have,shown,participates,initiation,progression,diabetic,atherosclerosis,through,pathological,mechanisms,such,dysfunction,insulin,resistance,endothelial,monocyte,adhesion,infiltration,smooth,muscle,proliferation,migration,medicine,has,been,proven,effective,response,mediated,This,review,summarizes,latest,pathogenesis,potential,treatment
AB值：
0.630378
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