典型文献
Biosynthesis, bioactivity, biotoxicity and applications of antimicrobial peptides for human health
文献摘要：
Antimicrobial peptides (AMPs) are the natural antibiotics recognized for their broad-spectrum resistance to bacteria, fungi, viruses and parasites, and influencing the host immune responses. AMPs attributed to good biological effects have been used in various areas of human health, which are trying to completely replace antibiotics, owing to serious drug-resistance bacteria. However, limited bioactivity and potential biotoxicity of some AMPs was neglected, attributable to their hydrophobic structure with positive charges and nonspecific destruction of cell membranes. Various strategies have been used to design and biosynthetic optimized AMPs to improve their bioactivity, productivity, while lowering host toxicity and cost. Here, we focus on the progress made in understanding the AMPs, including biosynthesis (AMP-BioDesign 1.0 and 2.0), bioactivity (e.g. immune regulation and broad-spectrum or nonspecific actions against bacteria, viruses or parasites), and principle biotoxicity (e.g. hemolysis, acute toxicity and instability, ect). The application prospects of AMP for human health, clinical medicine (for novel drugs), tissue engineering and drug delivery system, respectively, are summarized in this review. Furthermore, future prospects and new strategy for the development of effective and low-toxic AMP formulations for human health are discussed.
文献关键词：
Biosafety;Antimicrobial peptides;Synthetic biology;Human health;CRISPR/Cas9
中图分类号：
作者姓名：
Wei Daixu;Zhang Xuwei
作者机构：
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi’an 710069, China
文献出处：
引用格式：
[1]Wei Daixu;Zhang Xuwei-.Biosynthesis, bioactivity, biotoxicity and applications of antimicrobial peptides for human health)[J].生物安全与健康 （英文）,2022(02):118-134
A类：
BioDesign,Biosafety
B类：
Biosynthesis,bioactivity,biotoxicity,applications,antimicrobial,peptides,human,health,Antimicrobial,AMPs,natural,antibiotics,recognized,their,broad,spectrum,resistance,bacteria,fungi,viruses,parasites,influencing,host,immune,responses,attributed,good,biological,effects,have,been,used,various,areas,which,trying,completely,replace,owing,serious,However,limited,potential,some,was,neglected,attributable,hydrophobic,structure,positive,charges,nonspecific,destruction,cell,membranes,Various,strategies,design,biosynthetic,optimized,improve,productivity,while,lowering,cost,Here,focus,progress,made,understanding,including,biosynthesis,regulation,actions,against,principle,hemolysis,acute,instability,prospects,clinical,medicine,novel,drugs,tissue,engineering,delivery,system,respectively,summarized,this,review,Furthermore,future,new,strategy,development,effective,formulations,discussed,Synthetic,biology,Human,CRISPR,Cas9
AB值：
0.566194
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