典型文献
Updates on CRISPR-based gene editing in HIV-1/AIDS therapy
文献摘要：
Although tremendous efforts have been made to prevent and treat HIV-1 infection,HIV-1/AIDS remains a major threat to global human health.The combination antiretroviral therapy(cART),although able to suppress HIV-1 replication,cannot eliminate the proviral DNA integrated into the human genome and thus requires lifelong treatment that may lead to various side effects.In recent years,clustered regularly interspaced short palindromic repeat(CRISPR)-associated nuclease 9(Cas9)related gene-editing systems have been developed and designed as effective ways to treat HIV-1 infection.However,new gene-targeting tools derived from or functioning like CRISPR/Cas9,including base editor,prime editing,SHERLOCK,DETECTR,PAC-MAN,ABACAS,pfAGO,have been developed and optimized for pathogens detection and diseases correction.Here,we summarize recent studies on HIV-1/AIDS gene therapy and provide more gene-editing targets based on studies relating to the molecular mechanism of HIV-1 infection.We also identify the strategies and potential applications of these new gene-editing technologies for HIV-1/AIDS treatment in the future.Moreover,we discuss the caveats and problems that should be addressed before the clinical use of these versatile CRISPR-based gene targeting tools.Finally,we offer alternative solutions to improve the practice of gene targeting in HIV-1/AIDS gene therapy.
文献关键词：
中图分类号：
作者姓名：
Zhihao Zhang;Wei Hou;Shuliang Chen
作者机构：
Institute of Medical Virology,School of Basic Medical Sciences,Wuhan University,Wuhan,430071,China
文献出处：
引用格式：
[1]Zhihao Zhang;Wei Hou;Shuliang Chen-.Updates on CRISPR-based gene editing in HIV-1/AIDS therapy)[J].中国病毒学,2022(01):1-10
A类：
proviral,SHERLOCK,DETECTR,ABACAS,pfAGO,caveats
B类：
Updates,CRISPR,gene,editing,HIV,AIDS,therapy,Although,tremendous,efforts,have,been,made,prevent,infection,remains,major,threat,global,human,health,combination,antiretroviral,cART,although,able,suppress,replication,cannot,eliminate,integrated,into,genome,thus,requires,lifelong,treatment,that,may,lead,various,side,effects,In,recent,years,clustered,regularly,interspaced,short,palindromic,repeat,associated,nuclease,Cas9,related,systems,developed,designed,effective,ways,However,new,targeting,tools,derived,from,functioning,like,including,editor,prime,PAC,MAN,optimized,pathogens,detection,diseases,correction,Here,summarize,studies,provide,more,targets,relating,molecular,mechanism,We,also,identify,strategies,potential,applications,these,technologies,future,Moreover,discuss,problems,should,addressed,before,clinical,use,versatile,Finally,offer,alternative,solutions,improve,practice
AB值：
0.5727
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