典型文献
The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection
文献摘要：
Innate immune cells are critical for transplant response.As an important cellular component of innate immune cells,macrophages are the predominate infiltrated cells in allografts,and macrophage accumu-lation in allografts is negatively associated with the short-and long-term outcomes of organ transplan-tation.Macrophages are functionally heterogeneous and plastic.They participate in organ graft rejection through multiple pathways,including antigen presentation,the expression of costimulatory molecules and cytokines,and direct cytotoxicity and injury ability to allografts.However,some macrophage sub-populations,such as regulatory macrophages,can protect allografts from immune rejection and promote transplant immune tolerance with their immune regulatory properties.Although researchers recognize the potential roles macrophages play in allograft injury,they pay insufficient attention to the diverse roles of macrophages in allograft rejection.We herein briefly summarize the distinctive roles of macro-phages in acute transplant immune response and the effect of immunosuppressive drugs on macro-phages.Greater attention should be paid to the complex and critical function of macrophages in allograft rejection,and more effort should be put into developing immunosuppressive drugs that specifi-cally target macrophages,which would ultimately improve the long-term survival of organ grafts in patients.
文献关键词：
中图分类号：
作者姓名：
Liang Tan;Yinan Guo;Chang Feng;Yangxiao Hou;Xubiao Xie;Yong Zhao
作者机构：
Kidney Transplantation Department,The Second Xiangya Hospital of Central South University,Changsha 410011,China;State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;Cunji Medical School,University of Chinese Academy of Sciences,Beijing 100049,China;Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China
文献出处：
引用格式：
[1]Liang Tan;Yinan Guo;Chang Feng;Yangxiao Hou;Xubiao Xie;Yong Zhao-.The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection)[J].工程（英文）,2022(03):21-29
A类：
transplan
B类：
Dual,Regulatory,Roles,Macrophages,Acute,Allogeneic,Organ,Graft,Rejection,Innate,immune,cells,are,critical,transplant,response,important,cellular,component,innate,macrophages,predominate,infiltrated,allografts,accumu,negatively,associated,short,long,term,outcomes,organ,functionally,heterogeneous,plastic,They,participate,rejection,through,multiple,pathways,including,antigen,presentation,expression,costimulatory,molecules,cytokines,direct,cytotoxicity,injury,ability,However,some,sub,populations,such,regulatory,can,protect,from,promote,tolerance,their,properties,Although,researchers,recognize,potential,roles,play,they,pay,insufficient,attention,diverse,We,herein,briefly,summarize,distinctive,acute,effect,immunosuppressive,drugs,Greater,should,be,paid,complex,more,effort,put,into,developing,that,specifi,cally,target,which,would,ultimately,improve,survival,patients
AB值：
0.56971
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