典型文献
Prognostic Utility of Serum Cystatin C/FT3 Ratio Combined with NT-proBNP in Patients with Heart Failure: A Retrospective Cohort Study
文献摘要：
Heart failure (HF) is a serious and advanced stage of heart disease that has remained a major public health threat despite advances in medical therapy. HF prevalence in developed countries is 1.5％–2.0％and significantly increases with age, with a reported HF prevalence of ≥ 10％ in patients aged > 70 years[1]. Moreover, HF is associated with poor quality of life and has a five-year mortality rate of up to 50％[2]. HF is a complex syndrome involving different pathophysiological pathways (e.g., remodeling, myocardial injury, fibrosis, and inflammation), the components of which can be reflected by some biomarkers. The most used diagnostic and prognostic HF biomarker is the N-terminal B-type natriuretic peptide precursor (NT-proBNP) due to its longer plasma half-life and less biological variation compared to the B-type natriuretic peptide precursor (BNP)[3]. There has been extensive research on other biomarkers, including cystatin C (Cys-C) and free triiodothyronine (FT3), with prognostic value in patients with HF. When HF occurs, renal insufficiency activates the renin-angiotensin-aldosterone and sympathetic nervous systems, resulting in fluid retention, increasing cardiac preload, and aggravating pump failure. Cys-C is an early indicator of kidney injury that is involved in the pathological process of HF development. In patients with HF, chronic tissue hypoxia, gastrointestinal mucosal and liver congestion, and reduced protein intake and synthesis will lead to hypermetabolic thyroxine disorder, increasment of thyroxine receptor level, and inhibition of T4 transformation into T3, resulting in the increase of T3 clearance rate and decrease in plasma T3 level.
文献关键词：
中图分类号：
作者姓名：
WANG Chuan He;HAN Su;TONG Fei;LI Ying;LI Zhi Chao;SUN Zhi Jun
作者机构：
Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning, China
文献出处：
引用格式：
[1]WANG Chuan He;HAN Su;TONG Fei;LI Ying;LI Zhi Chao;SUN Zhi Jun-.Prognostic Utility of Serum Cystatin C/FT3 Ratio Combined with NT-proBNP in Patients with Heart Failure: A Retrospective Cohort Study)[J].生物医学与环境科学（英文版）,2022(05):453-457
A类：
hypermetabolic,increasment
B类：
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AB值：
0.664013
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