典型文献
Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats
文献摘要：
Objective: To evaluate the ethanol extract of Voacanga grandifolia for hepatoprotective and antioxidant potential against ethanol-induced liver toxicity in rats.Methods: Sprague-Dawley rats were administered ethanol (7 g/kg) and then treated with 100 and 200 mg/kg of Voacanga grandifolia extract. The phytochemical constituents and antioxidant potential of Voacanga grandifolia extract were evaluated by GC-MS and in vitro antioxidant assays. Biochemical indicators for liver damage and pro-apoptotic and antiapoptotic gene expression were determined using biochemical kits, ELISA, and qRT-PCR, respectively. Additionally, histopathological study of the liver was performed. Results: GC-MS identified propanoic acid, meso-erythritol, D-pinitol, myo-inositol, and hexadecanoic acid in Voacanga grandifolia extract. Voacanga grandifolia extract (100 and 200 mg/kg) increased the concentration of enzymatic antioxidants while diminishing the levels of inflammatory cytokines and biochemical indicators. qRT-PCR assay showed that Voacanga grandifolia extracts upregulated antiapoptotic gene expression while downregulating pro-apoptotic gene expression. Furthermore, the plant extract improved the hepatic architecture of ethanol-intoxicated rats. Conclusions: Voacanga grandifolia extract demonstrates hepatoprotective activity against alcohol-induced liver injury in rats and could be a potential hepatoprotective agent.
文献关键词：
中图分类号：
作者姓名：
Lal Chand Pal;Shivankar Agrawal;Arti Gautam
作者机构：
Pharmacology Division,CSIR-National Botanical Research Institute,Lucknow 226001,Uttar Pradesh,India;Department of Phytochemistry,ICMR-National Institute of Traditional Medicine,Nehru Nagar,Belagavi 590010,Karnataka,India;Department of Pharmaceutical Sciences,Sam Higginbottom University of Agriculture,Technology&Sciences,Naini,Prayagraj 211007,Uttar Pradesh,India
文献出处：
引用格式：
[1]Lal Chand Pal;Shivankar Agrawal;Arti Gautam-.Voacanga grandifolia (Miq.) Rolfe protects against alcohol-induced liver toxicity in rats)[J].亚太热带生物医学杂志（英文版）,2022(12):504-511
A类：
Voacanga,pinitol,hexadecanoic
B类：
grandifolia,Miq,Rolfe,protects,against,alcohol,induced,liver,toxicity,rats,Objective,To,ethanol,hepatoprotective,potential,Methods,Sprague,Dawley,were,administered,then,treated,phytochemical,constituents,evaluated,by,vitro,assays,Biochemical,indicators,damage,antiapoptotic,gene,expression,determined,using,biochemical,kits,qRT,respectively,Additionally,histopathological,study,was,performed,Results,identified,propanoic,acid,meso,erythritol,myo,inositol,increased,concentration,enzymatic,antioxidants,while,diminishing,levels,inflammatory,cytokines,showed,that,extracts,upregulated,downregulating,Furthermore,plant,improved,hepatic,architecture,intoxicated,Conclusions,demonstrates,activity,injury,could,be,agent
AB值：
0.464632
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