典型文献
In-vitro and in-vivo pharmacological screening of Iris albicans
文献摘要：
OBJECTIVE:To evaluate the anti-oxidant,enzyme inhibition,anti-pyretic,anti-inflammatory and anti-diabetic activities of Iris albicans.METHODS:Anti-oxidant assay was evaluated using DPPH(2,2-diphenyl-1-picrylhydrazyl)radical scavenging and ABTS(2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid)inhibitory protocol while enzyme inhibitory assay was evaluated by lipoxygenase and cyclooxygenase-2 inhibitory protocol respectively.Anti-pyretic,anti-inflammatory and anti-diabetic potential was evaluated using brewer's yeast induced pyrexia,carrageenan induced paw edema and streptozocin induced diabetes protocols respectively.Serum biochemical parameters were monitored for the period of study.RESULTS:The anti-oxidant activity of chloroform fraction of Iris albicans showed the highest scavenging potential against DPPH and ABTS while the maximum inhibitory action recorded against lipo-oxygenase and cyclo-oxygenase-2 enzymes was shown by n-hexane and chloroform fractions respectively.The anti-pyretic potential of the crude methanolic extract showed dose dependent activity in reducing pyrexia,thereby when the dose was increased the anti-pyretic effect was also enhanced.The anti-inflammatory action of the crude methanolic extract administered at the dose of 300 mg/kg was significant at 1 h after its administration,which was found maintained up to 5 h.Similarly the anti-diabetic effect of the crude methanolic extract administered at the dose of 200 and 300 mg/kg was noted highly significant at day 6 and was found well maintained throughout the study time period up to 10 days.Significant(P＜0.001)improvement appeared in hemoglobin,protein,cholesterol,triglycerides,urea,creatinine,HDL and LDL of extract treated diabetic mice.CONCLUSION:From this data it could be concluded that Iris albicans have significant anti-oxidant,enzyme inhibition,ant-pyretic,anti-inflammatory and anti-diabetic potential.
文献关键词：
中图分类号：
作者姓名：
Dawood Kamal;Roohullah;Fazle Rabbi;Attiqa Naz;Muhammad Bilal
作者机构：
Department of Pharmacy,Abasyn University Peshawar,Peshawar,25000,Khyber Pakhtunkhwa,Pakistan
文献出处：
引用格式：
[1]Dawood Kamal;Roohullah;Fazle Rabbi;Attiqa Naz;Muhammad Bilal-.In-vitro and in-vivo pharmacological screening of Iris albicans)[J].中医杂志（英文版）,2022(01):9-16
A类：
pyretic,brewer,pyrexia
B类：
In,vitro,vivo,pharmacological,screening,Iris,albicans,OBJECTIVE,To,anti,oxidant,inhibition,inflammatory,diabetic,activities,METHODS,Anti,assay,was,evaluated,using,DPPH,diphenyl,picrylhydrazyl,radical,scavenging,ABTS,azino,bis,ethylbenzothiazoline,sulfonic,acid,inhibitory,while,lipoxygenase,cyclooxygenase,respectively,potential,yeast,induced,carrageenan,paw,edema,streptozocin,diabetes,protocols,Serum,biochemical,parameters,were,monitored,period,study,RESULTS,activity,chloroform,showed,highest,against,maximum,recorded,enzymes,shown,hexane,fractions,crude,methanolic,extract,dose,dependent,reducing,thereby,when,increased,effect,also,enhanced,administered,significant,after,its,administration,which,found,maintained,up,Similarly,noted,highly,well,throughout,days,Significant,improvement,appeared,hemoglobin,protein,cholesterol,triglycerides,urea,creatinine,HDL,LDL,treated,mice,CONCLUSION,From,this,data,could,concluded,that,have
AB值：
0.465839
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