典型文献
Evaluation of silymarin extract from Silybum marianum in mice: anti-fatigue activity
文献摘要：
Silymarin has been used for centuries for its hepatoprotective properties. The specific objective of this study was to evaluate the anti-fatigue properties of silymarin. The silymarin was administered orally at doses of 50, 100, and 200 mg/kg for 4 weeks; the fatigue level and exercise performance were evaluated using exhaustive swimming time and pole-climbing time, as well as levels of plasma lactate, ammonia, glucose, creatine kinase (CK), serum urea nitrogen (SUN), blood lactic acid (BLA), muscle glycogen (MG), and liver glycogen (LG) contents after an intensive swimming session. The results demonstrated that silymarin treatment decreased the BLA and SUN levels while increased the LG and MG levels. In addition, silymarin decreased plasma lactate and ammonia levels and CK activity after swimming test, this is related to the mechanism that increases energy storage (as glycogen) and release (as blood glucose), and decreases plasma levels of lactate, ammonia, and CK. The observation of the skeletal muscle structures of mice also confirmed that skeletal muscles became more damaged in the control group compared with the silymarin-treated mice after prolonged endurance exercise. Therefore, it is reasonable to infer that silymarin may bear potential pharmacological effects in combating fatigue.
文献关键词：
中图分类号：
作者姓名：
Luming Jia;Fei Zhao
作者机构：
College of Food Science and Engineering,Dalian Ocean University,Dalian 116023,China
文献出处：
引用格式：
[1]Luming Jia;Fei Zhao-.Evaluation of silymarin extract from Silybum marianum in mice: anti-fatigue activity)[J].食品科学与人类健康（英文）,2022(04):914-921
A类：
Silybum,marianum,Silymarin
B类：
Evaluation,silymarin,extract,from,mice,anti,fatigue,activity,has,been,used,centuries,its,hepatoprotective,properties,specific,objective,this,study,was,administered,orally,doses,weeks,exercise,performance,were,evaluated,using,exhaustive,swimming,pole,climbing,well,levels,plasma,lactate,ammonia,glucose,creatine,kinase,serum,urea,nitrogen,SUN,blood,lactic,acid,BLA,glycogen,MG,liver,LG,contents,after,intensive,session,results,demonstrated,that,treatment,decreased,while,increased,In,addition,test,related,mechanism,increases,energy,storage,release,decreases,observation,skeletal,structures,also,confirmed,muscles,became,more,damaged,control,group,compared,treated,prolonged,endurance,Therefore,reasonable,infer,may,bear,potential,pharmacological,effects,combating
AB值：
0.530525
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
