典型文献
Pharmacological insights into Chukrasia velutina bark: Experimental and computer- aided approaches
文献摘要：
Background : Chukrasia velutina is an enthnomedicinally used plant reported to have significant medicinal values. The present study aimed to explore the pharmacological activities of bark methanol extract using in vitro, in vivo and in silico models. Methods : The study was designed to investigate the pharmacological effects of methanol extract of Chukrasia velutina bark (MECVB) through in vitro, in vivo and in silico assays. Analgesic activity was tested using formalin-i nduced nociception and acetic acid-i nduced writhing assays while the antipyretic effect was tested using yeast-i nduced hyperthermia in mice model. The antioxidant effect was tested using the DPPH and reducing power assay and the cytotoxic screening was tested using the brine shrimp lethality bioassay. In addition, in silico studies were conducted using computer aided methods. Results : In the acetic acid-i nduced writhing assay, the extract showed 28.36％ and 56.16％ inhibition of writhing for doses of 200 and 400 mg/kg, respectively. Moreover, a dose- dependent formalin- induced licking response was observed in both early and late phase. In yeast-i nduced pyrexia, the MECVB exhibited ( p < 0.05) antipyretic ef-fect. The extract demonstrated an IC 50 value of 78.86 μg/ml compared with ascor-bic acid (IC 5023.53 μg/ml) in the DPPH scavenging assay. The compounds sitosterol, 5,7- dimethoxycoumarin and scopoletin were seen be effective in molecular docking scores against COX- I (2OYE), COX-Ⅱ (6COX) and human peroxiredoxin 5 (1HD2). In ADME/T analysis, 5,7- dimethoxycoumarin and scopoletin satisfied Lipinski' s rule of five and thus are potential drug candidates. Conclusion : The bark of Chukrasia velutina showed significant analgesic and antipy-retic properties and is a potential source of natural anti- oxidative agents.
文献关键词：
中图分类号：
作者姓名：
Israt Jahan;Shahenur Alam Sakib;Najmul Alam;Mohuya Majumder;Sanjida Sharmin;A.S.M.Ali Reza
作者机构：
Department of Pharmacy,International Islamic University Chittagong,Chittagong,Bangladesh;Department of Pharmacy,East West University,Dhaka,Bangladesh
文献出处：
引用格式：
[1]Israt Jahan;Shahenur Alam Sakib;Najmul Alam;Mohuya Majumder;Sanjida Sharmin;A.S.M.Ali Reza-.Pharmacological insights into Chukrasia velutina bark: Experimental and computer- aided approaches)[J].动物模型与实验医学（英文）,2022(04):377-388
A类：
Chukrasia,enthnomedicinally,MECVB,nduced,licking,pyrexia,dimethoxycoumarin,2OYE,6COX,1HD2,antipy,retic
B类：
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AB值：
0.468686
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