典型文献
Association of serum potassium level with early and late mortality in very elderly patients with acute kidney injury
文献摘要：
Background::The kidneys play a central role in serum potassium (
K+) homeostasis, and their dysfunction leads to electrolyte disorders. We aimed to examine the relationship between different levels of
K+ and mortality among very elderly patients with acute kidney injury (AKI).
Methods::We retrospectively enrolled very elderly patients (≥75 years) with AKI from the hospital information system of the Chinese PLA General Hospital from January 1, 2007 to December 31, 2018. All-cause mortality was examined according to six predefined
K+ levels: <3.50 mmol/L, 3.50-3.79 mmol/L, 3.80-4.09 mmol/L, 4.10-4.79 mmol/L, 4.80-5.49 mmol/L, and ≥5.50 mmol/L. We estimated the risk of all-cause mortality using the multivariable adjusted Cox proportional hazard model with the normal
K+ level at 3.50-3.79 mmol/L as a reference.
Results::In total, 747 patients were deemed suitable for the final evaluation. The median age of the 747 participants was 88 (84-91) years. After 90 days, the mortality rates in the six strata were 28.3%, 21.9%, 30.1%, 35.4%, 45.2%, and 58.3%, respectively. In the multivariable adjusted analysis, patients with
K+ levels of 4.10-4.79 mmol/L (hazard ratio [HR]: 1.638; 95% confidence interval [CI]: 1.016-2.642), 4.80-5.49 mmol/L (HR: 2.585; 95% CI: 1.524-4.384), and ≥5.50 mmol/L (HR: 2.587; 95% CI: 1.495-4.479) had an increased risk of all-cause mortality. After 1 year, the mortality rates in the six strata were 44.8%, 41.1%, 45.1%, 51.8%, 63.1%, and 76.3%, respectively. In the multivariable adjusted analysis, patients with
K+ levels of 4.10-4.79 mmol/L (HR: 1.452; 95% CI: 1.014-2.079), 4.80-5.49 mmol/L (HR: 2.151; 95% CI: 1.427-3.241), and ≥5.50 mmol/L (HR: 2.341; 95% CI: 1.514-3.620) had an increased risk of all-cause mortality.
Conclusion::Increased serum
K+ levels, including levels of 4.10-5.49 mmol/L and ≥5.50 mmol/L, were associated with a significantly increased short- and long-term risk of death. Serum
K+ has the potential to be a marker of disease severity among very elderly patients with AKI.
文献关键词：
Hyperkalemia;Hypokalemia;Serum potassium;Acute kidney injury;Elderly;Mortality
中图分类号：
作者姓名：
Li Qinglin;Li Yuru;Zhou Feihu
作者机构：
Department of Critical Care Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China;Department of Laboratory Test, The Second Medical Centre, Chinese PLA General Hospital, Beijing 100853, China;Chinese PLA General Hospital National Clinical Research Center for Geriatric Diseases, Beijing 100853, China
文献出处：
引用格式：
[1]Li Qinglin;Li Yuru;Zhou Feihu-.Association of serum potassium level with early and late mortality in very elderly patients with acute kidney injury)[J].重症医学（英文）,2022(01):50-55
A类：
with
,Hyperkalemia,Hypokalemia
B类：
Association,serum,potassium,early,late,mortality,very,elderly,patients,acute,injury,Background,kidneys,play,central,role,K+,homeostasis,their,dysfunction,leads,electrolyte,disorders,We,aimed,relationship,between,different,levels,among,AKI,Methods,retrospectively,enrolled,years,from,hospital,information,system,Chinese,PLA,General,Hospital,January,December,All,cause,was,examined,according,six,predefined,estimated,risk,all,using,multivariable,adjusted,Cox,proportional,hazard,model,normal,reference,Results,total,were,deemed,suitable,final,evaluation,median,age,participants,After,days,rates,strata,respectively,analysis,ratio,confidence,interval,had,increased,Conclusion,Increased,including,associated,significantly,short,long,term,death,Serum,has,potential,marker,disease,severity,Acute,Elderly,Mortality
AB值：
0.440321
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
