典型文献
Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV
文献摘要：
Background::Few data are available regarding the long-term case-fatality rate (CFR) among people living with HIV (PLWH) with nontuberculous mycobacteria (NTM) disease. The aim of this study is to analyze the long-term CFR in patients with NTM disease and to identify risk factors for their death.Methods::A retrospective cohort study of 379 cases of microbiologically confirmed NTM disease in PLWH was conducted from January 1, 2012, to December 31, 2020, in Shanghai, China. We used Kaplan-Meier survival analysis and the log-rank test to compare the long-term CFR in patients with disseminated NTM (DNTM) and localized NTM disease. Univariate Cox proportional hazards regression analysis and a stepwise Cox proportional hazards regression model were used to estimate the predictors of long-term CFR.Results::The cohort was followed up for a median of 26 months. The total CFR was 15.7% by one year and increased to 22.6% at 5 years after the diagnosis of NTM disease. The 5-year CFR of PLWH with DNTM was significantly higher than that of PLWH with localized NTM (26.7% vs 19.6% for DNTM and localized NTM disease, respectively). Older age [hazard ratio (HR)= 1.04, 95% confidence interval (
CI): 1.02-1.06,
P < 0.001], comorbidity (HR= 2.05, 95%
CI: 1.21-3.49,
P < 0.01), DNTM (HR= 2.08, 95%
CI: 1.17-3.68,
P < 0.05), and HIV viral load (HR= 1.32, 95%
CI: 1.12-1.55,
P < 0.001) were all independent risk factors for long-term CFR. In the subgroup analysis, time to culture positivity was negatively correlated with CFR in patients with DNTM (HR= 0.90, 95%
CI: 0.82-0.98,
P < 0.05).
Conclusions::NTM was associated with a high long-term CFR in PLWH. Further approaches to prevent NTM disease in PLWH are urgently needed.
文献关键词：
HIV/AIDS;Nontuberculous mycobacteria;Case-fatality rate;Risk factor
中图分类号：
作者姓名：
Hu Jingjing;Gu Ling;Shao Yueming;Zhang Renfang;Qi Tangkai;Sun Jianjun;Wang Zhenyan;Song Wei;Tang Yang;Wang Jiangrong;Xu Shuibao;Yang Junyang;Shen Yinzhong;Liu Li;Chen Jun;Lu Hongzhou
作者机构：
School of Public Health, Bengbu Medical College, Bengbu 233000, Anhui, China;Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jinshan District, Shanghai 201508, China;Shenzhen Third People’s Hospital, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518000, China
文献出处：
引用格式：
[1]Hu Jingjing;Gu Ling;Shao Yueming;Zhang Renfang;Qi Tangkai;Sun Jianjun;Wang Zhenyan;Song Wei;Tang Yang;Wang Jiangrong;Xu Shuibao;Yang Junyang;Shen Yinzhong;Liu Li;Chen Jun;Lu Hongzhou-.Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV)[J].贫困所致传染病（英文）,2022(01):47-55
A类：
DNTM
B类：
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AB值：
0.443509
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