典型文献
Negative association of time in range and urinary albumin excretion rate in patients with type 2 diabetes mellitus: a retrospective study of inpatients
文献摘要：
Background::Time in range (TIR) refers to the time an individual spends within their target glucose range, which now has been popularized as an important metric to classify glycemic management and also recognized as an important outcome of current diabetes therapies. This study aimed to investigate the association between TIR and the severity of the urinary albumin excretion rate (UAER) in patients with type 2 diabetes mellitus (T2DM).Methods::We retrospectively analyzed the data of 1014 inpatients with T2DM at the Department of Endocrinology and Metabolism of Peking University International Hospital, China. TIR was defined as the percentage of blood glucose within the target range of 3.90-10.00 mmol/L. Urine samples for assessment of UAER were collected for 3 consecutive days from the start of hospitalization.Results::The TIR values for patients with normal urine levels of albumin, microalbuminuria, and macroalbuminuria were 70% ± 20%, 50% ± 20%, and 30% ± 20%, respectively (all
P < 0.001). The patients were stratified according to quartiles of TIR as follows: quartile (Q) 1, <55%; Q2, 55%-72%; Q3, 73%-83%; and Q4, >83%. The incidences of microalbuminuria in Q1, Q2, Q3, and Q4 were 41.1%, 21.6%, 7.1%, and 5.5% (all
P < 0.001), respectively. The respective incidences of macroalbuminuria were 24.2%, 1.1%, 1.4%, and 0% (all
P < 0.001). In multinomial logistic regression analyses, TIR was significantly correlated with microalbuminuria (odds ratio [OR] 0.58, 95% confidence interval [CI]: 0.52-0.65,
P < 0.001) and macroalbuminuria (OR 0.26, 95% CI: 0.18-0.38,
P < 0.001) after adjusting for age, sex, body mass index, diabetes duration, systolic blood pressure, and levels of triglycerides, glycosylated hemoglobin A1c, and creatinine.
Conclusion::The proportion of blood glucose in TIR is closely related to the severity of UAER in patients with T2DM.
文献关键词：
Time in range;Type 2 diabetes;Urinary albumin excretion rate;Blood glucose
中图分类号：
作者姓名：
Chai Sanbao;Wu Shanshan;Xin Sixu;Yuan Ning;Sun Jianbin;Zhang Xiaomei;Ji Linong
作者机构：
Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing 102206, China;National Clinical Research Center of Digestive Diseases, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing 100050, China;Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing 100044, China
文献出处：
引用格式：
[1]Chai Sanbao;Wu Shanshan;Xin Sixu;Yuan Ning;Sun Jianbin;Zhang Xiaomei;Ji Linong-.Negative association of time in range and urinary albumin excretion rate in patients with type 2 diabetes mellitus: a retrospective study of inpatients)[J].中华医学杂志（英文版）,2022(09):1052-1056
A类：
spends,macroalbuminuria
B类：
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AB值：
0.502324
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